Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

COVID-19 Therapeutic Potential of Natural Products

Zhaoxuan Low
,
Rafidah Lani
ORCID logo ,
Vunjia Tiong
* ,
Chitlaa Poh
ORCID logo ,
Sazaly AbuBakar
ORCID logo ,
Pouya Hassandarvish
* ORCID logo
Version 1 : Received: 6 May 2023 / Approved: 8 May 2023 / Online: 8 May 2023 (09:34:31 CEST)

A peer-reviewed article of this Preprint also exists.

Low, Z.; Lani, R.; Tiong, V.; Poh, C.; AbuBakar, S.; Hassandarvish, P. COVID-19 Therapeutic Potential of Natural Products. Int. J. Mol. Sci. 2023, 24, 9589. Low, Z.; Lani, R.; Tiong, V.; Poh, C.; AbuBakar, S.; Hassandarvish, P. COVID-19 Therapeutic Potential of Natural Products. Int. J. Mol. Sci. 2023, 24, 9589.

Abstract

Despite the fact that COVID-19 treatment and management are now considerably regulated, SARS-CoV-2 is still one of the leading causes of death in 2022. The availability of COVID-19 vaccines, FDA-approved antivirals, and monoclonal antibodies in low-income countries still poses an issue to be addressed. Natural products, particularly traditional Chinese medicines (TCMs) and medicinal plant extracts (or their active component) have challenged the dominance of drug repurposing and synthetic compound libraries in COVID-19 therapeutics. Abundant resources and excellent antiviral performance make natural products a relatively cheap and easily available alternative for COVID-19 therapeutics. Here, we deliberately review the anti-SARS-CoV-2 mechanisms of the natural products, their potency (pharmacological profiles), and application strategies for COVID-19 intervention. In light of their advantages, this review is intended to acknowledge the potential of natural products as COVID-19 therapeutic candidates.

Keywords

COVID-19; SARS-CoV-2; antiviral; therapeutics; natural products; traditional Chinese medicines; plant extracts

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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