Article
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Anti-mitochondrial Therapy: A New Dimension of Personalized Oncology
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Version 1
: Received: 7 May 2023 / Approved: 8 May 2023 / Online: 8 May 2023 (08:48:56 CEST)
A peer-reviewed article of this Preprint also exists.
Behnam, B.; Taghizadeh-Hesary, F. Mitochondrial Metabolism: A New Dimension of Personalized Oncology. Cancers 2023, 15, 4058. Behnam, B.; Taghizadeh-Hesary, F. Mitochondrial Metabolism: A New Dimension of Personalized Oncology. Cancers 2023, 15, 4058.
Abstract
Energy is needed by cancer cells to stay alive and communicate with their surroundings. The primary organelles for cellular metabolism and energy synthesis are mitochondria. Researchers recently proved that cancer cells can steal immune cells' mitochondria using nanoscale tubes. This finding demonstrates the dependence of cancer cells on normal cells for their living and function. It also denotes the importance of mitochondria in cancer cells’ biology. Emerging evidence has demonstrated how mitochondria are essential for cancer cells to survive in the harsh tumor microenvironment, evade the immune system, obtain more aggressive features, and resist treatments. For instance, functional mitochondria can improve cancer resistance against radiotherapy by scavenging the released reactive oxygen species. Therefore, targeting mitochondria can potentially enhance oncological outcomes, according to this notion. The patients' reactions to radiation are varied, ranging from a complete response to even cancer progression during treatment. This concept illustrates how different levels of mitochondrial metabolism might contribute to this heterogeneity. Considering this notion can help to improve personalized oncological treatments. This article outlines the importance of mitochondrial metabolism in cancer biology and personalized treatments.
Keywords
Mitochondria; Personalized Oncology; cancer stem cell; T Cell
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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