Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

A Novel Approach to Treat Peripheral Artery Disease

Version 1 : Received: 6 May 2023 / Approved: 8 May 2023 / Online: 8 May 2023 (05:38:31 CEST)

How to cite: Blum, A. A Novel Approach to Treat Peripheral Artery Disease. Preprints 2023, 2023050459. https://doi.org/10.20944/preprints202305.0459.v1 Blum, A. A Novel Approach to Treat Peripheral Artery Disease. Preprints 2023, 2023050459. https://doi.org/10.20944/preprints202305.0459.v1

Abstract

Atherosclerosis is a dynamic, chronic and progressive process that involves the vascular bed (coronary and peripheral). Risk factors are associated with the progression rate and with the evolution of atherosclerosis. There are traditional risk factors and non-traditional risk factors, all of them lead to endothelial dysfunction. Endothelial dysfunction plays a key factor in atherosclerosis. It accompanies hypercholesterolemia, diabetes, hypertension, cigarette smoking – leading to the development of atherosclerosis. Endothelial dysfunction can be reversed by treating hyperlipidemia and other damaging processes, and the mechanism is believed to be associated with an increase in vascular endogenous NO. PAD is a devastating disease, leading to leg pain and amputation. Until now the optional treatments don’t cure or prevent the uneventful outcome, but may slow the downhill progression. We summarize the updated knowledge of the management of PAD and suggest a novel approach to treat patients with PAD, using stem cells technology and a special novel endovascular device that will deliver the cells continuously on the long run and may halt the progression of atherosclerosis or even cure PAD.

Keywords

PAD; CLI; Stem cells therapy; endovascular device

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

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