Damps, M.; Byrska-Maciejasz, E.; Kowalska, M.; Rosada-Kurasińska, J.; Rybojad, B.; Sordyl, J.; Zielińska, M.; Bartkowska-Śniatkowska, A.; on behalf of the PAPITCO-19 Group. COVID-19 in Pediatric Intensive Care Units in Poland, PAPITCO-19 Study (Polish Analysis of PICU Trends during COVID-19). J. Clin. Med.2023, 12, 3983.
Damps, M.; Byrska-Maciejasz, E.; Kowalska, M.; Rosada-Kurasińska, J.; Rybojad, B.; Sordyl, J.; Zielińska, M.; Bartkowska-Śniatkowska, A.; on behalf of the PAPITCO-19 Group. COVID-19 in Pediatric Intensive Care Units in Poland, PAPITCO-19 Study (Polish Analysis of PICU Trends during COVID-19). J. Clin. Med. 2023, 12, 3983.
Damps, M.; Byrska-Maciejasz, E.; Kowalska, M.; Rosada-Kurasińska, J.; Rybojad, B.; Sordyl, J.; Zielińska, M.; Bartkowska-Śniatkowska, A.; on behalf of the PAPITCO-19 Group. COVID-19 in Pediatric Intensive Care Units in Poland, PAPITCO-19 Study (Polish Analysis of PICU Trends during COVID-19). J. Clin. Med.2023, 12, 3983.
Damps, M.; Byrska-Maciejasz, E.; Kowalska, M.; Rosada-Kurasińska, J.; Rybojad, B.; Sordyl, J.; Zielińska, M.; Bartkowska-Śniatkowska, A.; on behalf of the PAPITCO-19 Group. COVID-19 in Pediatric Intensive Care Units in Poland, PAPITCO-19 Study (Polish Analysis of PICU Trends during COVID-19). J. Clin. Med. 2023, 12, 3983.
Abstract
Background: Children suffering from COVID-19 constitute about 10% of the entire population infected with the virus. In most of them, we observe asymptomatic or mild course; however, about 1% of affected children require a stay in the pediatric intensive care unit (PICU) due to the severe life-threatening course. The risk of respiratory failure, as in adults, is associated with the coexistence of concomitant diseases. The aim of our study was to analyze patients admitted to PICUs due to severe course of SARS-CoV-19 infection. Methods: A retrospective multi-center study, the analysis covered all children with a confirmed diagnosis of SARS-CoV-2 virus infection, who were admitted to PICUs, in the period from November 2020 to August 2021. We studied epidemiological and laboratory parameters, and the endpoint – survival or death. Results: The study analyzed 45 patients (0.075% of all children hospitalized in Poland due to COVID-19 at that time). Mortality calculated in the entire study group was 40% (n=18). Statistically significant differences between the compared groups (survived and died) concerned the parameters of the respiratory system, Lung Injury Score and Pediatric Sequential Organ Failure Assessment . A significant correlation between disease severity and the patient's prognosis was shown by the liver function parameter AST (p=0.028). Analyzing patients requiring mechanical ventilation and assuming survival as the primary outcome, a significantly higher oxygen index on the first day of hospitalization, lower pSOFA scores and lower AST levels (p: 0.007; 0.043; 0.020; 0.005; 0.039, respectively) were found. Conclusions: As in adults, children with comorbidities are most frequently at risk of severe SARS-CoV-2 infection. Increasing symptoms of respiratory failure, the need for mechanical ventilation and persistently high values of aspartate aminotransferase are indicators of poor prognosis.
Keywords
SARS-CoV-2; pandemic; children infection; respiratory failure
Subject
Medicine and Pharmacology, Clinical Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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