Cyclodextrins Inclusion Complexes Improving Antibacterial Drug Profiles: An Update Systematic Review

Anamaria Mendonça Santos; José Adão Carvalho Do Nascimento Júnior; Silvia Vitória Silva Cézar; Lucindo José Quintans Júnior; Adriano Antunes de Souza Araújo; Diana Marcela Aragón; Mairim Russo Serafini

doi:10.20944/preprints202304.0953.v1

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preprints.org > medicine and pharmacology > pharmacy > doi: 10.20944/preprints202304.0953.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Cyclodextrins Inclusion Complexes Improving Antibacterial Drug Profiles: An Update Systematic Review

Anamaria Mendonça Santos

^* ,

José Adão Carvalho Do Nascimento Júnior

Silvia Vitória Silva Cézar

Lucindo José Quintans Júnior

Adriano Antunes de Souza Araújo

Diana Marcela Aragón

Mairim Russo Serafini

Version 1 : Received: 25 April 2023 / Approved: 26 April 2023 / Online: 26 April 2023 (04:09:37 CEST)

A peer-reviewed article of this Preprint also exists.

Santos, A.M.; Júnior, J.A.; Cézar, S.V.; Araújo, A.A.; Júnior, L.J.; Aragón, D.M.; Serafini, M.R. Cyclodextrin Inclusion Complexes Improving Antibacterial Drug Profiles: An Update Systematic Review. Future Microbiology 2023, doi:10.2217/fmb-2023-0124. Santos, A.M.; Júnior, J.A.; Cézar, S.V.; Araújo, A.A.; Júnior, L.J.; Aragón, D.M.; Serafini, M.R. Cyclodextrin Inclusion Complexes Improving Antibacterial Drug Profiles: An Update Systematic Review. Future Microbiology 2023, doi:10.2217/fmb-2023-0124.

Abstract

Antibiotics have become a widely used drug classes worldwide. Its indiscriminate use in the clini-cal-hospital environment ended up causing antibiotic-resistance genes. Pharmaceutical technology is an essential ally for new formulation development in the antibacterial field. Cyclodextrins (CDs) are ap-proaches that can potentially improve the effectiveness of antibacterial drugs. Thus, this study aimed to review experimental models using CDs as inclusion complexes to improve antibacterial drugs’ physi-cochemical characteristics and biological activities. The review was carried out using the three online journals database PubMed, Scopus, and Embase, limited to Medical Subjects Headings Index. The search protocol was registered in the Open Science Framework database. The following terms and their com-binations were used: cyclodextrins and antibacterial agents in title or abstract, and a total of 1580 studies were identified in a period up to October 2022. Finally, 27 articles were selected for discussion in this review. The biological results reveal that the antibacterial effect of the compounds, complexed with CDs, was extensively improved when compared to the free drugs. CDs can improve the therapeutic effects of antibiotics, already existing on the market, natural products, and synthetic molecules. Therefore, these inclusion complexes using CDs increase the new pharmaceutical products development for clinical ap-plication.

Keywords

Antibacterial Agents; Antibiotics; Cyclodextrins; Inclusion Complex; Technology; Treatments

Subject

Medicine and Pharmacology, Pharmacy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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