Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Endoscopic Diagnosis Strategy of Raspberry-Shaped Gastric Lesion in Helicobacter pylori-Uninfected Patient

Nobuyuki Suzuki
ORCID logo ,
Atsushi Ikeda
,
Hiroya Ueyama
* ORCID logo ,
Noboru Yatagai
,
Yasuko Uemura
,
Momoko Yamamoto
,
Tomoyo Iwano
,
Hisanori Utsunomiya
,
Ryota Uchida
,
Daiki Abe
,
Shotaro Oki
ORCID logo ,
Yoichi Akazawa
,
Tsutomu Takeda
ORCID logo ,
Kumiko Ueda
,
Mariko Hojo
ORCID logo ,
Takashi Yao
ORCID logo ,
Akihito Nagahara
ORCID logo
Version 1 : Received: 21 April 2023 / Approved: 23 April 2023 / Online: 23 April 2023 (08:12:59 CEST)

How to cite: Suzuki, N.; Ikeda, A.; Ueyama, H.; Yatagai, N.; Uemura, Y.; Yamamoto, M.; Iwano, T.; Utsunomiya, H.; Uchida, R.; Abe, D.; Oki, S.; Akazawa, Y.; Takeda, T.; Ueda, K.; Hojo, M.; Yao, T.; Nagahara, A. Endoscopic Diagnosis Strategy of Raspberry-Shaped Gastric Lesion in Helicobacter pylori-Uninfected Patient. Preprints 2023, 2023040791. https://doi.org/10.20944/preprints202304.0791.v1 Suzuki, N.; Ikeda, A.; Ueyama, H.; Yatagai, N.; Uemura, Y.; Yamamoto, M.; Iwano, T.; Utsunomiya, H.; Uchida, R.; Abe, D.; Oki, S.; Akazawa, Y.; Takeda, T.; Ueda, K.; Hojo, M.; Yao, T.; Nagahara, A. Endoscopic Diagnosis Strategy of Raspberry-Shaped Gastric Lesion in Helicobacter pylori-Uninfected Patient. Preprints 2023, 2023040791. https://doi.org/10.20944/preprints202304.0791.v1

Abstract

Objectives: We aimed to clarify the endoscopic and clinicopathological features of raspberry-shaped gastric lesions (RSGLs) and to establish an endoscopic diagnostic algorithm for RSGLs. Methods: We collected RSGLs from an endoscopic database at our hospital between May 2009 and August 2021. All RSGLs were histopathologically classified and compared based on their endoscopic and clinicopathological characteristics. Results: Sixty-five RSGLs in 54 patients were classified into five histopathological types: gastric adenocarcinoma of foveolar type (GA-FV, n = 43), gastric adenocarcinoma of fundic-gland type (GA-FG, n = 2), gastric adenocarcinoma of fundic-gland mucosa type (GA-FGM, n = 4), hyperplastic polyp (HP, n = 12), and proton pump inhibitor-related lesion (PPI-L, n = 4). All RSGLs exhibited polygonal or curved marginal crypt epithelium (MCE). GA-FV lesions had homogenously reddish (95%) and irregular microvascular (MV) pattern (91%). GA-FG lesions were heterogeneously reddish with a submucosal tumor shape (100%) and had a regular MV pattern (50%). GA-FGM lesions were homogenously reddish (75%) and occasionally had a submucosal tumor shape (50%) with an irregular MV pattern (75%). HP and PPI-L were homogeneously reddish (93%), with linear or dotted MCE (81%) and a regular MV pattern (100%). Conclusion: Our diagnostic algorithm for RSGLs constructed using endoscopic features might be useful for the endoscopic differential diagnosis of RSGLs.

Keywords

Helicobacter pylori-uninfected gastric cancer; gastric adenocarcinoma of foveolar type; raspberry-shaped gastric lesion; gastric adenocarcinoma of fundic-gland type; gastric adenocarcinoma of fundic-gland mucosa type; hyperplastic polyp; proton pump inhibitor-related lesion; early gastric cancer.

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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