Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Uses and Challenges of Antiviral Polyclonal and Monoclonal Antibody Therapies

Version 1 : Received: 17 April 2023 / Approved: 18 April 2023 / Online: 18 April 2023 (08:30:07 CEST)

A peer-reviewed article of this Preprint also exists.

Struble, E.B.; Rawson, J.M.O.; Stantchev, T.; Scott, D.; Shapiro, M.A. Uses and Challenges of Antiviral Polyclonal and Monoclonal Antibody Therapies. Pharmaceutics 2023, 15, 1538. Struble, E.B.; Rawson, J.M.O.; Stantchev, T.; Scott, D.; Shapiro, M.A. Uses and Challenges of Antiviral Polyclonal and Monoclonal Antibody Therapies. Pharmaceutics 2023, 15, 1538.

Abstract

Viral diseases represent a major public health concern and an ever-present risk for developing into a future pandemic. Antiviral antibody therapeutics, either alone or in combination with other therapies, have emerged as valuable preventative and treatment options, including during a global emergency. Here we will discuss polyclonal and monoclonal antiviral antibody therapies, focusing on the unique biochemical and physiological properties that make them well suited as therapeutic agents. We will describe the methods of antibody characterization and potency assessment throughout development, highlighting similarities and differences between polyclonal and monoclonal products as appropriate. In addition, we will consider the benefits and challenges of antiviral antibodies when used in combination with other antibodies or other types of antiviral therapeutics. Lastly, we will discuss novel approaches to the characterization and development of antiviral antibodies and identify areas that would benefit from additional research.

Keywords

antiviral therapy; antiviral antibodies; antibody combination therapy; antibody potency; potency assays

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

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