Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Neonatal Drug Formularies: a Global Scope

Dotan Shaniv
ORCID logo ,
Srinivas Bolisetty
,
Thomas E. Young
,
Barry Mangum
,
Sean Ainsworth
,
Linda Elbers
,
Petra Schultz
,
Melanie Cucchi
,
Saskia N De Wildt
,
Tjitske M Van der Zanden
,
Neil Caldwell
,
Anne Smits
ORCID logo ,
Karel Allegaert
* ORCID logo
Version 1 : Received: 12 April 2023 / Approved: 12 April 2023 / Online: 12 April 2023 (09:32:12 CEST)

A peer-reviewed article of this Preprint also exists.

Shaniv, D.; Bolisetty, S.; Young, T.E.; Mangum, B.; Ainsworth, S.; Elbers, L.; Schultz, P.; Cucchi, M.; de Wildt, S.N.; van der Zanden, T.M.; Caldwell, N.; Smits, A.; Allegaert, K. Neonatal Drug Formularies—A Global Scope. Children 2023, 10, 848. Shaniv, D.; Bolisetty, S.; Young, T.E.; Mangum, B.; Ainsworth, S.; Elbers, L.; Schultz, P.; Cucchi, M.; de Wildt, S.N.; van der Zanden, T.M.; Caldwell, N.; Smits, A.; Allegaert, K. Neonatal Drug Formularies—A Global Scope. Children 2023, 10, 848.

Abstract

Neonatal drug information (DI) is essential for safe and effective pharmacotherapy in (pre)term neonates. Such information is usually absent from drug labels, making formularies a crucial part of the neonatal clinician’s toolbox. Several formularies exist worldwide, but they have never been fully mapped nor compared for content, structure and workflow. The objective of this review was to identify neonatal formularies, explore (dis)similarities, and raise awareness of their existence.Neonatal formularies were identified through self-acquaintance, experts and structured search. A questionnaire was sent to all identified formularies to provide details on formulary function. An original extraction tool was employed to collect DI from the formularies on the 10 most commonly used drugs in pre(term) neonates.Eight different neonatal formularies were identified worldwide (Europe, USA, Australia-New Zealand, Middle East). Six responded to the questionnaire and were compared for structure and content. Each formulary has its own workflow, monograph template and style, and update routine. Focus on certain aspects of DI also varies, as well as the type of initiative and funding.Clinicians should be aware of the various formularies available and their differences in characteristics and content to use them properly for the benefit of their patients.

Keywords

Drug information; drug database; drug formulary; neonatal; pediatric

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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