Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Vector Competence of Aedes albopictus for Yellow Fever Virus: Risk of Reemergence of Urban Yellow Fever in Brazil

Rossela Damasceno Caldeira
ORCID logo ,
Joaquim Pinto Nunes Neto
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Carine Fortes Aragão
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Maria Nazaré Oliveira Freitas
ORCID logo ,
Milene Silveira Ferreira
,
Paulo Henrique Gomes de Castro
,
Daniel Damous Dias
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Pedro Arthur da Silva Araújo
,
Roberto Carlos Feitosa Brandão
,
Bruno Tardelli Diniz Nunes
ORCID logo ,
Eliana Vieira Pinto da Silva
,
Lívia Caricio Martins
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Pedro Fernando da Costa Vasconcelos
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Ana Cecília Ribeiro Cruz
* ORCID logo
Version 1 : Received: 17 March 2023 / Approved: 20 March 2023 / Online: 20 March 2023 (02:01:29 CET)

A peer-reviewed article of this Preprint also exists.

Damasceno-Caldeira, R.; Nunes-Neto, J.P.; Aragão, C.F.; Freitas, M.N.O.; Ferreira, M.S.; Castro, P.H.G.; Dias, D.D.; Araújo, P.A.S.; Brandão, R.C.F.; Nunes, B.T.D.; Silva, E.V.P.; Martins, L.C.; Vasconcelos, P.F.C.; Cruz, A.C.R. Vector Competence of Aedes albopictus for Yellow Fever Virus: Risk of Reemergence of Urban Yellow Fever in Brazil. Viruses 2023, 15, 1019. Damasceno-Caldeira, R.; Nunes-Neto, J.P.; Aragão, C.F.; Freitas, M.N.O.; Ferreira, M.S.; Castro, P.H.G.; Dias, D.D.; Araújo, P.A.S.; Brandão, R.C.F.; Nunes, B.T.D.; Silva, E.V.P.; Martins, L.C.; Vasconcelos, P.F.C.; Cruz, A.C.R. Vector Competence of Aedes albopictus for Yellow Fever Virus: Risk of Reemergence of Urban Yellow Fever in Brazil. Viruses 2023, 15, 1019.

Abstract

The risk of the emergence and reemergence of zoonoses is high in regions that are under anthropogenic actions, as they contribute to the risk of vector disease transmission. Yellow fever (YF) is among the main pathogenic arboviral disease in the world, and the Culicidae Aedes albopictus has been proposed to have the potential to transmit yellow fever virus (YFV). This mosquito inhabits both urban and wild environments, and under experimental conditions, it has been shown to be susceptible to infection by YFV. In this study, the vector competence of the mosquito Ae. albopictus for the YFV was investigated. Female Ae. albopictus were exposed to non-human primates (NHP) of the genus Callithrix infected with YFV for blood meal. Subsequently, on the 14th and 21st days post infection, the legs, heads, thorax/abdomen and saliva of the arthropods were collected and analyzed by viral isolation and molecular analysis techniques to verify the infection, dissemination and transmission. The presence of YFV was detected in saliva samples through viral isolation and in the head, thorax/abdomen and legs both by viral isolation and by molecular detection. The susceptibility of Ae. Albopictus to YFV confers a potential risk of reemergence of urban YF in Brazil.

Keywords

infecção experimental; Aedes albopictus; febre amarela; reemergência; RT‒qPCR; isolamento viral

Subject

Arts and Humanities, Film, Radio and Television

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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