Version 1
: Received: 3 March 2023 / Approved: 6 March 2023 / Online: 6 March 2023 (07:00:00 CET)
How to cite:
Srinivasan Rajsri, K.; Singh, M.; Rao, M. Efficacy of COVID-19 Vaccines Against the Omicron Variant of SARS-CoV-2. Preprints2023, 2023030097. https://doi.org/10.20944/preprints202303.0097.v1.
Srinivasan Rajsri, K.; Singh, M.; Rao, M. Efficacy of COVID-19 Vaccines Against the Omicron Variant of SARS-CoV-2. Preprints 2023, 2023030097. https://doi.org/10.20944/preprints202303.0097.v1.
Cite as:
Srinivasan Rajsri, K.; Singh, M.; Rao, M. Efficacy of COVID-19 Vaccines Against the Omicron Variant of SARS-CoV-2. Preprints2023, 2023030097. https://doi.org/10.20944/preprints202303.0097.v1.
Srinivasan Rajsri, K.; Singh, M.; Rao, M. Efficacy of COVID-19 Vaccines Against the Omicron Variant of SARS-CoV-2. Preprints 2023, 2023030097. https://doi.org/10.20944/preprints202303.0097.v1.
Abstract
The severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) Omicron variant of concern has been the dominant cause of worldwide COVID-19 cases since 2022. All the Omicron sublineage viruses have demonstrated high transmissibility and an ability to escape vaccine-induced immunity. While first-generation vaccines, including monovalent vaccines, continue to provide protection against severe disease, hospitalization and mortality, their efficacy against Omicron sub variants remains sparse. These vaccines have also been associated with rapidly waning protection against primary COVID-19 and COVID-19 reinfections conferred by evolving Omicron sublineages.. This led to the development and deployment of updated vaccines and the introduction of the bivalent booster. Through this review, we highlight the brief journey of the variants of concern leading to the dominance of Omicron and the effectiveness of the key vaccines against these variants, including the updated (bivalent) boosters.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
