Zhang, Y.; Wang, L.; Kang, H.; Lin, C.-Y.; Fan, Y. Unlocking the Therapeutic Potential of Irisin: Harnessing Its Function in Degenerative Disorders and Tissue Regeneration. Int. J. Mol. Sci.2023, 24, 6551.
Zhang, Y.; Wang, L.; Kang, H.; Lin, C.-Y.; Fan, Y. Unlocking the Therapeutic Potential of Irisin: Harnessing Its Function in Degenerative Disorders and Tissue Regeneration. Int. J. Mol. Sci. 2023, 24, 6551.
Zhang, Y.; Wang, L.; Kang, H.; Lin, C.-Y.; Fan, Y. Unlocking the Therapeutic Potential of Irisin: Harnessing Its Function in Degenerative Disorders and Tissue Regeneration. Int. J. Mol. Sci.2023, 24, 6551.
Zhang, Y.; Wang, L.; Kang, H.; Lin, C.-Y.; Fan, Y. Unlocking the Therapeutic Potential of Irisin: Harnessing Its Function in Degenerative Disorders and Tissue Regeneration. Int. J. Mol. Sci. 2023, 24, 6551.
Abstract
Physical activity is well-established as an important protective factor against degenerative conditions and a promoter of tissue growth and renewal. The discovery of FNDC5 as the precursor of irisin in 2012 sparked significant interest in its potential as a diagnostic biomarker and a therapeutic agent for various diseases. Clinical studies have examined the correlation between plasma irisin levels and pathological conditions using a range of assays, but the lack of reliable measurements for endogenous irisin has led to uncertainty about its prognostic/diagnostic potential as an exercise surrogate. Animal and tissue-engineering models have shown the protective effects of irisin treatment in reversing functional impairment and potentially permanent damage, but dosage ambiguities remain unresolved. This review provides a comprehensive examination of the clinical and basic studies of irisin in the context of degenerative conditions and explores its potential as a therapeutic approach in the physiological processes involved in tissue repair/regeneration.
Medicine and Pharmacology, Pathology and Pathobiology
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