Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Emerging Biomarkers and Potential Therapeutics of the BCL-2 Protein Family: The Apoptotic and Anti-Apoptotic Context

Shamrat Kumar Paul
ORCID logo ,
Md. Saddam
ORCID logo ,
Mohammad Ahsan Habib
,
Md. Abrar Fahim
,
Afsana Mimi
,
Saiful Islam
,
Bristi Paul
,
Md Mostofa Uddin Helal
* ORCID logo
Version 1 : Received: 21 February 2023 / Approved: 22 February 2023 / Online: 22 February 2023 (14:56:09 CET)

How to cite: Paul, S.K.; Saddam, M.; Habib, M.A.; Fahim, M.A.; Mimi, A.; Islam, S.; Paul, B.; Helal, M.M.U. Emerging Biomarkers and Potential Therapeutics of the BCL-2 Protein Family: The Apoptotic and Anti-Apoptotic Context. Preprints 2023, 2023020387. https://doi.org/10.20944/preprints202302.0387.v1 Paul, S.K.; Saddam, M.; Habib, M.A.; Fahim, M.A.; Mimi, A.; Islam, S.; Paul, B.; Helal, M.M.U. Emerging Biomarkers and Potential Therapeutics of the BCL-2 Protein Family: The Apoptotic and Anti-Apoptotic Context. Preprints 2023, 2023020387. https://doi.org/10.20944/preprints202302.0387.v1

Abstract

Apoptosis, also known as the programmed death of cells, is responsible for maintaining the homeostasis of tissues and this function is carried out by caspases. The process of apoptosis is carried out via two distinct pathways: the extrinsic pathway, which is governed by death receptors, and the intrinsic pathway, also known as the mitochondrial pathway. The BCL-2 protein family encoded by the BCL-2 gene, located at the 18q21.33 chromosomal location, is in charge of regulating the intrinsic pathway, which is responsible for inducing cell death via the permeabilization of the mitochondrial membrane and the release of apoptosis - inducing components. The BCL-2 homology (BH1, BH2, BH3, BH4) domains of this family proteins are crucial for their functioning and their common BH domains allow interactions between members of the same family and can also serve as indications of pro- or anti-apoptotic activity. A direct correlation may be shown between the overexpression of BCL-2 and the postponement of cell death. It has been determined that a change in the expression of BCL-2 is the root cause of a variety of malignancies, including lung, breast, melanoma, and chronic lymphocytic leukemia, Multiple Sclerosis, Diabetes. In this review, we discuss the therapeutic potential of regulating BCL-2 family connections and their relevance to health and disease.

Keywords

BCL-2 family protein; BCL-2 Domains; Apoptosis; Cancer; Biomarkers; Therapeutic Agents

Subject

Biology and Life Sciences, Cell and Developmental Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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