Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

First Clinical Comparison of STANDARD F TB-Feron FIA and the QIAreachTM QuantiFERON-TB for Tuberculosis Infection in Tertiary Public Hospital in South America

Version 1 : Received: 18 February 2023 / Approved: 20 February 2023 / Online: 20 February 2023 (13:37:31 CET)

A peer-reviewed article of this Preprint also exists.

Saint-Pierre, G.; Conei, D.; Cantillana, P.; Raijmakers, M.; Vera, A.; Gutiérrez, D.; Kennedy, C.; Peralta, P.; Ramonda, P. Comparison of Two Tuberculosis Infection Tests in a South American Tertiary Hospital: STANDARD F TB-Feron FIA vs. QIAreachTM QuantiFERON-TB. Diagnostics 2023, 13, 1162. Saint-Pierre, G.; Conei, D.; Cantillana, P.; Raijmakers, M.; Vera, A.; Gutiérrez, D.; Kennedy, C.; Peralta, P.; Ramonda, P. Comparison of Two Tuberculosis Infection Tests in a South American Tertiary Hospital: STANDARD F TB-Feron FIA vs. QIAreachTM QuantiFERON-TB. Diagnostics 2023, 13, 1162.

Abstract

Introduction: Tuberculosis (TB) is one of the most prevalent respiratory diseases in the world. In 2020 there were at least 9.9 million new infections, with 1.5 million deaths. Approximately 10% of people infected with Mycobacterium tuberculosis (LTBI) develop the disease during the first 2 to 5 years after infection. Currently in South America, the diagnosis of LTBI continues to be per-formed through the Mantoux tuberculin skin test (TST). Objective: The objective of our study was to compare the sensitivity of a new immunofluorescence IGRA test against a widely available IGRA kit on the market. Material and method: Close contact to infectious patients with TB, or HIV patients or immunocompromised for another cause were recruited. Two interferon gamma release assay (IGRA) diagnostic kits were used and compared with TST. Results: 76 patients were recruited. 93.42% were Chilean nationality, 98.68% of the patients did not have immunosuppres-sion. The sensitivity of the new technique was 88.89% and specificity 92.50% in the study popula-tion compared to the IGRA previously used. In the subgroup older than 36 years, the sensitivity was 95.65% and the specificity 89.47%. Conclusion: IGRA techniques are a new resource in clini-cal laboratories to be able to make an accurate diagnosis in LTBI in the region of the Americas. In our population, the greatest benefit of this new IGRA would be observed in people over 36 years of age, where the sensitivity of the technique was like that of the currently available test.

Keywords

Latent Tuberculoses; Latent Tuberculosis Infections; Koch's Disease; Interferon-gamma Release Assay; Tuberculin Tests; Rapid Diagnostic Test

Subject

Medicine and Pharmacology, Pulmonary and Respiratory Medicine

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