Version 1
: Received: 13 February 2023 / Approved: 14 February 2023 / Online: 14 February 2023 (07:52:01 CET)
How to cite:
Alam, S.B.; Kulka, M.; Wang, Y. Unravelling the Effects of Berberine on Metabolic Activity, Apoptosis and Proliferation of Transformed Cells. Preprints2023, 2023020238. https://doi.org/10.20944/preprints202302.0238.v1
Alam, S.B.; Kulka, M.; Wang, Y. Unravelling the Effects of Berberine on Metabolic Activity, Apoptosis and Proliferation of Transformed Cells. Preprints 2023, 2023020238. https://doi.org/10.20944/preprints202302.0238.v1
Alam, S.B.; Kulka, M.; Wang, Y. Unravelling the Effects of Berberine on Metabolic Activity, Apoptosis and Proliferation of Transformed Cells. Preprints2023, 2023020238. https://doi.org/10.20944/preprints202302.0238.v1
APA Style
Alam, S.B., Kulka, M., & Wang, Y. (2023). Unravelling the Effects of Berberine on Metabolic Activity, Apoptosis and Proliferation of Transformed Cells. Preprints. https://doi.org/10.20944/preprints202302.0238.v1
Chicago/Turabian Style
Alam, S.B., Marianna Kulka and Yanwen Wang. 2023 "Unravelling the Effects of Berberine on Metabolic Activity, Apoptosis and Proliferation of Transformed Cells" Preprints. https://doi.org/10.20944/preprints202302.0238.v1
Abstract
Berberine (BBR) is an isoquinoline that inhibits the proliferation of transformed cells in vitro, but due to its poor solubility and bioavailability, it has only moderate therapeutic potential in vivo. Increasing evidence indicates that BBR specifically targets several metabolic, signaling and gene transcription events in transformed cells, altering their progression through the cell cycle and decreasing their metabolic rate and proliferation. In order to further develop BBR as a therapeutic, its mode of cellular internalization and localization within the cell needs to be further examined. BBR’s molecular targets and interactions with kinases, transcription factors and some enzymes are discussed in an attempt to better understand BBR’s role in these important pathways and how they may lead to changes in metabolism. Lastly, this review examines some of the benefits and challenges of using BBR as an inhibitor in cancer cell proliferation in breast cancer and glioblastoma, as two examples. BBR is a potent drug with multiple targets and it is this multiplicity of function that makes BBR such a promising drug for targeting cell metabolism and proliferation.
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
