Version 1
: Received: 2 February 2023 / Approved: 7 February 2023 / Online: 7 February 2023 (02:51:51 CET)
How to cite:
Hanif, A.; Shahid, M.A.; Khan, K.; Qidwai, A. The Effect of Non-surgical Periodontal Therapy (NSPT) on the Systemic Inflammatory Markers (IL-6 and IL-8) in β-Thalassemia Patients with Gingivitis. Preprints2023, 2023020112. https://doi.org/10.20944/preprints202302.0112.v1
Hanif, A.; Shahid, M.A.; Khan, K.; Qidwai, A. The Effect of Non-surgical Periodontal Therapy (NSPT) on the Systemic Inflammatory Markers (IL-6 and IL-8) in β-Thalassemia Patients with Gingivitis. Preprints 2023, 2023020112. https://doi.org/10.20944/preprints202302.0112.v1
Hanif, A.; Shahid, M.A.; Khan, K.; Qidwai, A. The Effect of Non-surgical Periodontal Therapy (NSPT) on the Systemic Inflammatory Markers (IL-6 and IL-8) in β-Thalassemia Patients with Gingivitis. Preprints2023, 2023020112. https://doi.org/10.20944/preprints202302.0112.v1
APA Style
Hanif, A., Shahid, M.A., Khan, K., & Qidwai, A. (2023). The Effect of Non-surgical Periodontal Therapy (NSPT) on the Systemic Inflammatory Markers (IL-6 and IL-8) in β-Thalassemia Patients with Gingivitis. Preprints. https://doi.org/10.20944/preprints202302.0112.v1
Chicago/Turabian Style
Hanif, A., Komal Khan and Asim Qidwai. 2023 "The Effect of Non-surgical Periodontal Therapy (NSPT) on the Systemic Inflammatory Markers (IL-6 and IL-8) in β-Thalassemia Patients with Gingivitis" Preprints. https://doi.org/10.20944/preprints202302.0112.v1
Abstract
Periodontal diseases and Thalassemia Major (TM), which are two chronic inflammatory diseases, are associated with increased levels of proinflammatory cytokines in bio-fluids. Interleukin (IL)-6 and IL-8 have been identified as potent proinflammatory biomarkers in periodontal diseases as well as in patients with β-thalassemia (TM-β). This suggests that patients with TM-β and gingival inflammation have two chronic inflammatory conditions, each of which may affect the other. The objective of this pioneer research was to evaluate the effect of oral hygiene maintenance and care on serum levels of IL-6 and IL-8. 31 participants selected after screening and were given Non-surgical periodontal therapy(NSPT). IL-6 and IL-8 were evaluated by enzyme linked immunohistochemistry assay (ELISA) at baseline and compared at 6 weeks after NSPT. Statistical analysis was done with SPSS v23. The comparison from the baseline to 6-weeks follow-up for both IL-6 and IL-8 was done using Wilcoxon Signed rank test. The descriptive statistics are represented as median and inter quartile range (IQR). Highly significant improvement (p-<0.000) was found for IL-6 and IL-8 when compared at 6 weeks from baseline. Results provide a gateway to new modality in lowering systemic burden of the disease, thereby reducing morbidity, via local measures or oral care.
Medicine and Pharmacology, Dentistry and Oral Surgery
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
