Version 1
: Received: 23 January 2023 / Approved: 27 January 2023 / Online: 27 January 2023 (06:16:10 CET)
How to cite:
Ibancovichi, J.A.; Chávez-Monteagudo, J.R.; Sánchez-Aparicio, P.; De Paz-Campos, M.A. Chronic Use of the Synthetic Cannabinoid WIN 55,212-2 55 Modifies the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine. Preprints2023, 2023010488. https://doi.org/10.20944/preprints202301.0488.v1.
Ibancovichi, J.A.; Chávez-Monteagudo, J.R.; Sánchez-Aparicio, P.; De Paz-Campos, M.A. Chronic Use of the Synthetic Cannabinoid WIN 55,212-2 55 Modifies the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine. Preprints 2023, 2023010488. https://doi.org/10.20944/preprints202301.0488.v1.
Cite as:
Ibancovichi, J.A.; Chávez-Monteagudo, J.R.; Sánchez-Aparicio, P.; De Paz-Campos, M.A. Chronic Use of the Synthetic Cannabinoid WIN 55,212-2 55 Modifies the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine. Preprints2023, 2023010488. https://doi.org/10.20944/preprints202301.0488.v1.
Ibancovichi, J.A.; Chávez-Monteagudo, J.R.; Sánchez-Aparicio, P.; De Paz-Campos, M.A. Chronic Use of the Synthetic Cannabinoid WIN 55,212-2 55 Modifies the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine. Preprints 2023, 2023010488. https://doi.org/10.20944/preprints202301.0488.v1.
Abstract
The effects of morphine (MOR) and dexmedetomidine (DEX) on the MAC of isoflurane were measured in rats chronically treated with the synthetic cannabinoid WIN 55,212-2 (WIN55). Methods: The MAC of isoflurane was determined in 32 male rats from expiratory samples at the time of tail clamping. The effects of morphine (MAC(ISO+MOR)) and dexmedetomidine (MAC(ISO+DEX)) on the MAC of isoflurane in untreated rats and rats treated for 21 days with WIN 55,212-2 (MAC(ISO+WIN55+MOR)) and (MAC(ISO+WIN55+DEX)) were measured. Prior to the administration of morphine and dexmedetomidine, the MAC of the isoflurane was measured in both untreated rats (MAC(ISO)) and those treated with WIN 55,212-2 (MAC(ISO+WIN55)). Results: The minimum alveolar concentration was measured as 1.32 ± 0.06 in the MAC(ISO) group and 1.69 ± 0.09 in the MAC(ISO+WIN55) group. The MAC of the MAC(ISO+MOR) group was 0.97 ± 0.02 (26% less than the control group, MAC(ISO)). MAC was measured as 1.55 ± 0.08 in the MAC(ISO+WIN55+MOR) group (8% less than the MAC(ISO+WIN55) group), 0.68 ± 0.10 in the MAC(ISO+DEX) group (48% less than the control group, MAC(ISO)), and 0.67 ± 0.08 in the MAC(ISO+WIN55+DEX) group (60% less than the MAC(ISO+WIN55) group). Conclusions: The administration of WIN 55,212-2 for 21 days increases the MAC of isoflurane in rats. The sparing effect on isoflurane of morphine decreases in rats chronically treated with the synthetic cannabinoid, WIN 55,212-2. Dexmedetomidine increases its sparing effect on the minimum alveolar concentration of isoflurane in rats chronically treated with WIN 55,212-2.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
