Version 1
: Received: 13 January 2023 / Approved: 17 January 2023 / Online: 17 January 2023 (11:08:55 CET)
How to cite:
Pawelke, J.; Vinayahalingam, V.; El Khassawna, T.; Heiss, C.; Eckl, L.; Knapp, G. Complication and Infection Risk Using Bone Substitute Materials to Treat Long Bone Defects in Geriatric Patients– An Observational Study. Preprints2023, 2023010311. https://doi.org/10.20944/preprints202301.0311.v1
Pawelke, J.; Vinayahalingam, V.; El Khassawna, T.; Heiss, C.; Eckl, L.; Knapp, G. Complication and Infection Risk Using Bone Substitute Materials to Treat Long Bone Defects in Geriatric Patients– An Observational Study. Preprints 2023, 2023010311. https://doi.org/10.20944/preprints202301.0311.v1
Pawelke, J.; Vinayahalingam, V.; El Khassawna, T.; Heiss, C.; Eckl, L.; Knapp, G. Complication and Infection Risk Using Bone Substitute Materials to Treat Long Bone Defects in Geriatric Patients– An Observational Study. Preprints2023, 2023010311. https://doi.org/10.20944/preprints202301.0311.v1
APA Style
Pawelke, J., Vinayahalingam, V., El Khassawna, T., Heiss, C., Eckl, L., & Knapp, G. (2023). Complication and Infection Risk Using Bone Substitute Materials to Treat Long Bone Defects in Geriatric Patients– An Observational Study. Preprints. https://doi.org/10.20944/preprints202301.0311.v1
Chicago/Turabian Style
Pawelke, J., Larissa Eckl and Gero Knapp. 2023 "Complication and Infection Risk Using Bone Substitute Materials to Treat Long Bone Defects in Geriatric Patients– An Observational Study" Preprints. https://doi.org/10.20944/preprints202301.0311.v1
Abstract
When bone substitutes materials are used, the increased risk of infection due to the none-autogenic graft is often discussed. The treatment of large bone defects in geriatric patients, often with osteoporotic bone, often presents major challenges to surgery. Bone substitutes materials are available indefinitely without the risk of additional surgery in each patient. Can bone substitutes materials be used without hesitation in the geriatric patient? Eighty-three patients suffered traumatic fractures of the distal radius, proximal humerus, and proximal tibia. The defect zones were filled with bone substitute material based on nanocrystalline hydroxyapatite (NHA) or calcium phosphate (CP). For comparison, a reference group without the void filling with a bone graft substitute (void defects, ED) was studied. All patients over the age of 64 years were retrospectively evaluated for complications and radiological outcomes. Results: 106 patients sustained traumatic fractures of the distal radius (68.9%), proximal humerus (5.7%), and proximal tibia (22.6%). No differences in infections were found when comparing the groups (p=1.0). retrospectively evaluated. The KEM group had a nonsignificantly lower rate of pseudarthrosis (p=0.09). A relative risk (RR) reduction of complications of 32.64% was observed when bone grafting material was used. The NNT for the prevention of complications was 5.99. When bone healing was assessed by radiological images, some follow-up studies showed significant differences in fracture bridging (p<0.001). Conclusions: In contrast to previous studies, bone substitutes materials can support the healing process in geriatric patients without relevant disadvantages. With an NNT of 6 regarding complications, many patients could benefit from bone graft augmentation. No increased infection rate was observed.
Medicine and Pharmacology, Orthopedics and Sports Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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