Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Ceramides and Ceramide Synthases in Cancer: Focus on Apoptosis and Autophagy

Version 1 : Received: 14 January 2023 / Approved: 16 January 2023 / Online: 16 January 2023 (03:37:34 CET)

A peer-reviewed article of this Preprint also exists.

Alizadeh, J.; da Silva Rosa, S.C.; Weng, X.; Jacobs, J.; Lorzadeh, S.; Ravandi, A.; Vitorino, R.; Pecic, S.; Zivkovic, A.; Stark, H.; et al. Ceramides and Ceramide Synthases in Cancer: Focus on Apoptosis and Autophagy. European Journal of Cell Biology 2023, 151337, doi:10.1016/j.ejcb.2023.151337. Alizadeh, J.; da Silva Rosa, S.C.; Weng, X.; Jacobs, J.; Lorzadeh, S.; Ravandi, A.; Vitorino, R.; Pecic, S.; Zivkovic, A.; Stark, H.; et al. Ceramides and Ceramide Synthases in Cancer: Focus on Apoptosis and Autophagy. European Journal of Cell Biology 2023, 151337, doi:10.1016/j.ejcb.2023.151337.

Abstract

Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides’ fatty acid chain length, subcellular localization, and the presence or absence of their downstream targets. Our current understanding of the role of ceramide synthases and ceramides in regulation of apoptosis and autophagy could be harnessed to pioneer the development of new treatments to activate or inhibit a single type of ceramide synthase, thereby regulating the apoptosis induction or cross talk of apoptosis and autophagy in cancer cells. Moreover, the apoptotic function of ceramide suggests that ceramide analogues can pave the way for the development of novel cancer treatments. Therefore, in the current review paper we discuss the impact of ceramide synthases and ceramides in regulation of apoptosis and autophagy in context of different types of cancers. We also briefly introduce the latest methods to analyze the lipids in biological samples. Finally, we discuss the drug development strategies focusing on the ceramide synthases and ceramides as future therapeutic approaches in cancer therapy.

Keywords

mitochondrial cell death; autophagy cell death; lipidomic analysis; drug development

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

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