Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Intermittent Fasting Resolves Dyslipidemia and Atherogenesis in Apolipoprotein E-deficient Mice in a Diet-Dependent Manner, Irrespective of Sex

Version 1 : Received: 6 January 2023 / Approved: 9 January 2023 / Online: 9 January 2023 (10:49:54 CET)

A peer-reviewed article of this Preprint also exists.

Mérian, J.; Ghezali, L.; Trenteseaux, C.; Duparc, T.; Beuzelin, D.; Bouguetoch, V.; Combes, G.; Sioufi, N.; Martinez, L.O.; Najib, S. Intermittent Fasting Resolves Dyslipidemia and Atherogenesis in Apolipoprotein E-Deficient Mice in a Diet-Dependent Manner, Irrespective of Sex. Cells 2023, 12, 533. Mérian, J.; Ghezali, L.; Trenteseaux, C.; Duparc, T.; Beuzelin, D.; Bouguetoch, V.; Combes, G.; Sioufi, N.; Martinez, L.O.; Najib, S. Intermittent Fasting Resolves Dyslipidemia and Atherogenesis in Apolipoprotein E-Deficient Mice in a Diet-Dependent Manner, Irrespective of Sex. Cells 2023, 12, 533.

Abstract

In humans and animal models, intermittent fasting (IF) interventions promote body weight loss, improve metabolic health, and are thought to lower cardiovascular disease risk. However, there is a paucity of reports on the relevancy of such nutritional interventions in the context of dyslipidemia and atherosclerotic cardiovascular diseases. The present study assessed the metabolic and atheroprotective effects of intermittent fasting intervention (IF) in atherosclerosis-prone apolipoprotein E-deficient (Apoe-/-) mice. Groups of male and female Apoe-/- mice were fed a regular (chow) or atherogenic (high-fat, high-cholesterol, HFCD) diet for 4 months, either ad libitum or in an alternate-day fasting manner. The results show that IF intervention improved glucose and lipid metabolism independently of sex. However, IF only decreased body weight gain in males fed chow diet and differentially modulated adipose tissue parameters and liver steatosis in a diet composition-dependent manner. Finally, IF prevented spontaneous aortic atherosclerotic lesions formation in mice fed chow diet, irrespective of sex but failed to reduce HFCD-diet-induced atherosclerosis. Overall, the current work indicates that IF interventions can efficiently improve glucose homeostasis and treat atherogenic dyslipidemia, but a degree of caution is warranted with regard to the individual sex and the composition of the dietary regimen.

Keywords

Intermittent fasting; glucose tolerance; hepatic steatosis; adipose tissue; reverse cholesterol transport; atherosclerosis.

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.