Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Observational study on antibody response to COVID-19 Vaccines in pAtients with gastro-entero-panCreatic Cancers and neuroendocrIne NeoplAsms on systemic TreatmEnts (VACCINATE).

Alice Laffi
* ORCID logo ,
Lorenzo Gervaso
* ORCID logo ,
Oriana D'Ecclesiis
,
Sara Gandini
ORCID logo ,
Agostino Riva
,
Rita Passerini
,
Francesca Spada
ORCID logo ,
Stefania Pellicori
,
Manila Rubino
,
Chiara Alessandra Cella
,
Paola Simona Ravenda
,
Maria Giulia Zampino
,
Nicola Fazio
ORCID logo
Version 1 : Received: 3 January 2023 / Approved: 9 January 2023 / Online: 9 January 2023 (01:16:01 CET)

A peer-reviewed article of this Preprint also exists.

Laffi, A.; Gervaso, L.; D’Ecclesiis, O.; Gandini, S.; Riva, A.; Passerini, R.; Spada, F.; Pellicori, S.; Rubino, M.; Cella, C.A.; Ravenda, P.S.; Zampino, M.G.; Fazio, N. Observational Study on Antibody Response to COVID-19 Vaccines in PAtients with Gastro-Entero-PanCreatic Cancers and NeuroendocrIne NeoplAsms on Systemic TreatmEnts (VACCINATE). Biomedicines 2023, 11, 336. Laffi, A.; Gervaso, L.; D’Ecclesiis, O.; Gandini, S.; Riva, A.; Passerini, R.; Spada, F.; Pellicori, S.; Rubino, M.; Cella, C.A.; Ravenda, P.S.; Zampino, M.G.; Fazio, N. Observational Study on Antibody Response to COVID-19 Vaccines in PAtients with Gastro-Entero-PanCreatic Cancers and NeuroendocrIne NeoplAsms on Systemic TreatmEnts (VACCINATE). Biomedicines 2023, 11, 336.

Abstract

The Coronavirus disease-19 (COVID-19) pandemic dramatically impacted on oncologic patients' care. Since the introduction of vaccines and the demonstration of their benefit on frail patients, COVID-19 vaccinations were indicated also for oncologic population. However, data about the impact of anticancer-treatments and the timing between vaccinations and systemic therapy de-livery were not available. We aimed to evaluate potential factors influencing the outcome of COVID-19 vaccination in cancer patients. We prospectively collected data of patients undergoing COVID-19 vaccination with gas-tro-entero-pancreatic and neuroendocrine neoplasms, treated at our Institute, between 03/2021 and 12/2021. We enrolled 46 patients, 63.1% males; at the time of data collection 86.9% received two-doses of Pfizer-BioNTech and the remains Moderna vaccine. All patients obtained a subsequent im-mune-response. A significantly lower values of IgG for patients treated with chemotherapy versus other anti-cancer agents (p=0.004). No significant effect on immune-response was reported for both vaccinations performed ≤7 vs >7 days from the last systemic treatment (p=0.77) and lymphocytes count (p=0.11). The findings suggest that the optimal timing for COVID-19 vaccination and lymphocytes count are not the issue but rather the quality of the subset of lymphocytes before the vaccination to deter-mine the efficacy level of immune-response in this population.

Keywords

COVID; Sars-COV-2; Gastroenteropancreatic cancers; vaccines; neuroendocrine tumors

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.