Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

NGAL as Biomarker of Clinical and Subclinical Damage of Kidney Function after Coronary Angiography

Version 1 : Received: 31 December 2022 / Approved: 4 January 2023 / Online: 4 January 2023 (03:24:18 CET)

A peer-reviewed article of this Preprint also exists.

Petrova, I.; Alexandrov, A.; Vladimirov, G.; Mateev, H.; Bogov, I.; Paskaleva, I.; Gotcheva, N. NGAL as Biomarker of Clinical and Subclinical Damage of Kidney Function after Coronary Angiography. Diagnostics 2023, 13, 1180. Petrova, I.; Alexandrov, A.; Vladimirov, G.; Mateev, H.; Bogov, I.; Paskaleva, I.; Gotcheva, N. NGAL as Biomarker of Clinical and Subclinical Damage of Kidney Function after Coronary Angiography. Diagnostics 2023, 13, 1180.

Abstract

Contrast-induced acute kidney injury (CI-AKI) is a serious complication after angiographic examinations in cardiology. Diagnosis may be delayed based on standard serum creatinine, and subclinical forms of kidney damage may not be detected at all. In our study we investigate the clinical use in these directions of a “damage” type biomarker - Neutrophil Gelatinase-Associated Lipocalin (NGAL). Among patients with a high-risk profile undergoing scheduled coronary angiography and/or angioplasty, plasmsa NGAL was determined at baseline, at 4 and 24 hours after contrast administration. In the CI-AKI group, NGAL increased significantly at the 4th hour (132.33±72.83 ng/ml versus 111.48±65.06 ng/ml, p=0.006) and at the 24th hour (212 .93±276.61 ng/ml, p=0.008). In patients with subclinical CI-AKI, NGAL also increased significantly at the 4th hour (128.18±99 ng/ml, p=0.002) and reached levels close to those in patients with CI-AKI. Unlike new biomarker, however, serum creatinine did not change significantly in this group. The diagnostic power of NGAL is extremely good - AUC 0.847 (95% CI: 0.677-1.000; p=0.001) in CI-AKI and AUC 0.731 (95% CI: 0.539 – 0.924; p=0.024) in subclinical CI-AKI. NGAL may be a reliable biomarker for early diagnosis of clinical and subclinical forms of renal injury after contrast angiographic studies.

Keywords

Contrast-induced acute kidney injury (CI-AKI); subclinical CI-AKI; NGAL; contrast media; coro-nary angiography

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

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