Concept Paper
Version 1
Preserved in Portico This version is not peer-reviewed
Spiral Steroid (SS) Phosphodiesters: Role in Pregnancy
Version 1
: Received: 27 December 2022 / Approved: 28 December 2022 / Online: 28 December 2022 (12:24:39 CET)
How to cite: Chasalow, F. Spiral Steroid (SS) Phosphodiesters: Role in Pregnancy. Preprints 2022, 2022120541. https://doi.org/10.20944/preprints202212.0541.v1 Chasalow, F. Spiral Steroid (SS) Phosphodiesters: Role in Pregnancy. Preprints 2022, 2022120541. https://doi.org/10.20944/preprints202212.0541.v1
Abstract
Spiral steroids (SS) are a newly discovered type of steroid. Originally, they were described as cardiotonic glycosides because they cross-reacted with digoxin-specific antibodies (Digoxin-Like-Materials-DLM). SS differ from the classical steroids in several ways: [a] they are steroid phosphodiester conjugates and displace digoxin from digoxin-specific antibodies, [b] in contrast to all other steroids, cholesterol is not a precursor, [c] SS have more than 21 carbon atoms; the extra atoms form a 5th ring which includes a lactone, [d] SS bind to NaK-ATPase in membranes rather than receptors in the nucleus. SS have been identified by HPLC- mass spectroscopy in extracts from mammals, birds, and oysters but were not detected in plant extracts. Overall, SS seem to be key components in regulating potassium electrolytes during pregnancy and its related diseases – specifically pre-eclampsia and necrotizing enterocolitis.
Keywords
Ionotropin; Kaleotropin; Galotropin; Pre-eclampsia; Spiral Steroids; Necrotizing Enterocolitis; Cardiotonic glycosides; lactone; digoxin-like materials; DLM
Subject
Medicine and Pharmacology, Pulmonary and Respiratory Medicine
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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