Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Survival of Inpatients under 5 Years Old with Bronchiolitis by Laboratory-Confirmed Respiratory Syncytial Virus Infection

Oliver Mendoza-Cano
,
Xóchitl Trujillo
ORCID logo ,
Miguel Huerta
ORCID logo ,
Mónica Ríos-Silva
ORCID logo ,
José Guzmán-Esquivel
,
Verónica Benites-Godínez
,
Jaime Alberto Bricio-Barrios
ORCID logo ,
Eder Fernando Ríos-Bracamontes
,
Agustín Lugo-Radillo
* ORCID logo ,
Efrén Murillo-Zamora
* ORCID logo
Version 1 : Received: 27 December 2022 / Approved: 28 December 2022 / Online: 28 December 2022 (02:37:39 CET)

How to cite: Mendoza-Cano, O.; Trujillo, X.; Huerta, M.; Ríos-Silva, M.; Guzmán-Esquivel, J.; Benites-Godínez, V.; Bricio-Barrios, J.A.; Ríos-Bracamontes, E.F.; Lugo-Radillo, A.; Murillo-Zamora, E. Survival of Inpatients under 5 Years Old with Bronchiolitis by Laboratory-Confirmed Respiratory Syncytial Virus Infection. Preprints 2022, 2022120525. https://doi.org/10.20944/preprints202212.0525.v1 Mendoza-Cano, O.; Trujillo, X.; Huerta, M.; Ríos-Silva, M.; Guzmán-Esquivel, J.; Benites-Godínez, V.; Bricio-Barrios, J.A.; Ríos-Bracamontes, E.F.; Lugo-Radillo, A.; Murillo-Zamora, E. Survival of Inpatients under 5 Years Old with Bronchiolitis by Laboratory-Confirmed Respiratory Syncytial Virus Infection. Preprints 2022, 2022120525. https://doi.org/10.20944/preprints202212.0525.v1

Abstract

Background: The respiratory syncytial virus infection (RSV) spread has been unusually high during 2022 and increasing trends have been documented We aimed to assess the survival experience of children hospitalized due bronchiolitis by laboratory-confirmed RSV. Methods: A nationwide and retrospective cohort was conducted in Mexico and data from 436 children aged 5 years and younger, with symptoms onset from August 2021 to November 2022, were analyzed. Survivor functions and 95% confidence intervals (CI) were computed by using the Kaplan-Meier method. Results: The survival rates were high, particularly within the first three weeks of admission. The 3-day survival was 99.8% (CI 95% 98.4-99.9%) and went to 98.9% (CI 95% 96.5-99.7%), 97.5% (CI 95% 91.9-99.3%), 86.7% (95% CI 48.2-97.2%), and 69.4% (95% CI 24.2-91.0%) on days 7, 14, 21 and 28 of hospital stay, respectively. We documented 5 fatal outcomes, and the mortality rate was 2.1 per 1,000 person-days. Conclusions: We analyzed a large set of pediatric patients with bronchiolitis by RSV and the presented results contribute to achieving a better understanding of the in-hospital evolution of this disease.

Keywords

Respiratory Syncytial Virus Infections; Child; Bronchiolitis; Survival.

Subject

Medicine and Pharmacology, Pulmonary and Respiratory Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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