Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Effects of Ketogenic Diet on the Immune System: A Meta-Analysis

Version 1 : Received: 20 December 2022 / Approved: 21 December 2022 / Online: 21 December 2022 (09:04:52 CET)

How to cite: Tzenios, N.; Tazanios, M.E.; Poh, O.B.J.; Chahine, M. The Effects of Ketogenic Diet on the Immune System: A Meta-Analysis. Preprints 2022, 2022120395. https://doi.org/10.20944/preprints202212.0395.v1 Tzenios, N.; Tazanios, M.E.; Poh, O.B.J.; Chahine, M. The Effects of Ketogenic Diet on the Immune System: A Meta-Analysis. Preprints 2022, 2022120395. https://doi.org/10.20944/preprints202212.0395.v1

Abstract

Healthcare systems are mindful of the importance of proper diet and nutrition in reducing the risk of various chronic diseases resulting in hospitalizations. In this regard, they are focusing on promoting the intake of foods comprising various diets with health benefits, such as the ketogenic diet. In this meta-analysis, a total of 20 research studies on the effect of the ketogenic diet on the immune system were analyzed. The research studies were obtained from three databases: Google Scholar, PubMed, and Science Direct. From the meta-analysis, the odd ratio of a similar outcome of an improvement in the strength of immunity between the intervention and control group was 0.76. On the other hand, the p-value for the studies was 0.09, with 15 out of the 20 being considered statistically significant. The heterogeneity between the studies was I2 = 15%, signifying a low variability in the findings that is not by chance. The Ketogenic diet indeed has positive effects on immunity. Nonetheless, it can also result in negative effects that may harm human health.

Keywords

Ketogenic diet; obesity; overweight; metabolism; energy low carb foods

Subject

Biology and Life Sciences, Immunology and Microbiology

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