Version 1
: Received: 4 December 2022 / Approved: 5 December 2022 / Online: 5 December 2022 (07:07:46 CET)
How to cite:
Popovic, M. Everything you Always Wanted to Know about the Biothermodynamic Background of Herpes Simplex Virus Type 1 – Host Interaction. Preprints2022, 2022120063. https://doi.org/10.20944/preprints202212.0063.v1
Popovic, M. Everything you Always Wanted to Know about the Biothermodynamic Background of Herpes Simplex Virus Type 1 – Host Interaction. Preprints 2022, 2022120063. https://doi.org/10.20944/preprints202212.0063.v1
Popovic, M. Everything you Always Wanted to Know about the Biothermodynamic Background of Herpes Simplex Virus Type 1 – Host Interaction. Preprints2022, 2022120063. https://doi.org/10.20944/preprints202212.0063.v1
APA Style
Popovic, M. (2022). Everything you Always Wanted to Know about the Biothermodynamic Background of Herpes Simplex Virus Type 1 – Host Interaction. Preprints. https://doi.org/10.20944/preprints202212.0063.v1
Chicago/Turabian Style
Popovic, M. 2022 "Everything you Always Wanted to Know about the Biothermodynamic Background of Herpes Simplex Virus Type 1 – Host Interaction" Preprints. https://doi.org/10.20944/preprints202212.0063.v1
Abstract
Herpes simplex virus type 1 (HSV-1) is among the most widely spread viruses on the planet. However, the rate of binding to the receptor is not among the greatest ones. Gibbs energy of binding, which represents the driving force for antigen-receptor binding, of HSV-1 is less negative than can be expected. Furthermore, the Gibbs energy of biosynthesis of HSV-1 is among the most negative in nature. This implies high rate of multiplication of HSV-1. Obviously, HSV-1 uses specific strategy in virus-host interaction. While most other viruses increase infectivity through a high rate of antigen-receptor binding and cell entry/ highly negative Gibbs energy of binding, HSV-1 uses another strategy. It is related to a relatively slow reaction of antigen-receptor binding, which is followed by a higher rate of multiplication, which is a consequence of a highly negative Gibbs energy of biosynthesis. We can conclude empirically that both strategies are successful.
Keywords
Herpes simplex virus type 1 (HSV-1); antigen-receptor binding; equilibrium constant; Gibbs energy of binding; biothermodynamics
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
