Version 1
: Received: 29 November 2022 / Approved: 30 November 2022 / Online: 30 November 2022 (03:40:46 CET)
How to cite:
Pérez-Bautista, O.; Pérez-Padilla, R.; Ramírez-Venegas, A.; Velasco-Torres, Y.; Montaño, M.; Ramos, C. Eosinophilic Inflammation and Its Association with Small Airway Dysfunction in COPD Patients by Biomass. Preprints2022, 2022110560. https://doi.org/10.20944/preprints202211.0560.v1
Pérez-Bautista, O.; Pérez-Padilla, R.; Ramírez-Venegas, A.; Velasco-Torres, Y.; Montaño, M.; Ramos, C. Eosinophilic Inflammation and Its Association with Small Airway Dysfunction in COPD Patients by Biomass. Preprints 2022, 2022110560. https://doi.org/10.20944/preprints202211.0560.v1
Pérez-Bautista, O.; Pérez-Padilla, R.; Ramírez-Venegas, A.; Velasco-Torres, Y.; Montaño, M.; Ramos, C. Eosinophilic Inflammation and Its Association with Small Airway Dysfunction in COPD Patients by Biomass. Preprints2022, 2022110560. https://doi.org/10.20944/preprints202211.0560.v1
APA Style
Pérez-Bautista, O., Pérez-Padilla, R., Ramírez-Venegas, A., Velasco-Torres, Y., Montaño, M., & Ramos, C. (2022). Eosinophilic Inflammation and Its Association with Small Airway Dysfunction in COPD Patients by Biomass. Preprints. https://doi.org/10.20944/preprints202211.0560.v1
Chicago/Turabian Style
Pérez-Bautista, O., Martha Montaño and Carlos Ramos. 2022 "Eosinophilic Inflammation and Its Association with Small Airway Dysfunction in COPD Patients by Biomass" Preprints. https://doi.org/10.20944/preprints202211.0560.v1
Abstract
COPD is a chronic inflammatory disease characterized by progressive airflow obstruction. Tobacco smoking is the main cause of COPD (COPD-TS), but chronic exposure to biomass smoke (COPD-BS), mainly wood smoke, is the second risk factor; both are considered to cause different phenotypes of COPD. COPD-BS is more eosinophilic than COPD-TS. The objective of the present study was to evaluate the serum level of interleukins involved in eosinophil maturation, recruitment, and survival, and their association with small airway obstruction, measuring cytokines by multiplex test (Bio-Plex) and evaluating the central airway resistance with impulse oscillometry (IOS), comparatively in patients with COPD due to biomass and smoking. The results showed that IL-1ra, IL-2, IL-4, IL-8, IL-9, IL-13, IL-17, and eotaxin were increased in COPD-BS related to COPD-TS. Resistance parameters showed that R5, X5, AX (area reactance), and R5-R20 were significantly higher in COPD-BS than in the COPD-TS group (p < 0.05). R20 was not different between the groups. These data suggest that the cytokines involved in the effect of eosinophils on airway inflammation in COPD-BS were increased compared with COPD-TS, which appears to be related to a predominance of peripheral airway obstruction in patients with COPD-BS more than in COPD-TS
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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