Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Efficacy Assessment of Autodissemination using Pyriproxyfen-Treated Ovitraps in the Reduction of Dengue Incidence in Two Barangays in Parañaque City, Philippines: A Spatial Analysis

Antonio D. Ligsay
* ,
Zypher Jude G. Regencia
ORCID logo ,
Kristan Jela M. Tambio
,
Michelle Joyce M. Aytona
,
Alain Jason A. Generale
,
Grecebio Jonathan D. Alejandro
ORCID logo ,
Jacquiline S. Tychuaco
,
Lilian A. De las Llagas
,
Emmanuel S. Baja
ORCID logo ,
Richard Edward L. Paul
Version 1 : Received: 21 November 2022 / Approved: 21 November 2022 / Online: 21 November 2022 (09:44:35 CET)

A peer-reviewed article of this Preprint also exists.

Ligsay, A.D.; Regencia, Z.J.G.; Tambio, K.J.M.; Aytona, M.J.M.; Generale, A.J.A.; Alejandro, G.J.D.; Tychuaco, J.S.; De las Llagas, L.A.; Baja, E.S.; Paul, R.E.L. Efficacy Assessment of Autodissemination Using Pyriproxyfen-Treated Ovitraps in the Reduction of Dengue Incidence in Parañaque City, Philippines: A Spatial Analysis. Trop. Med. Infect. Dis. 2023, 8, 66. Ligsay, A.D.; Regencia, Z.J.G.; Tambio, K.J.M.; Aytona, M.J.M.; Generale, A.J.A.; Alejandro, G.J.D.; Tychuaco, J.S.; De las Llagas, L.A.; Baja, E.S.; Paul, R.E.L. Efficacy Assessment of Autodissemination Using Pyriproxyfen-Treated Ovitraps in the Reduction of Dengue Incidence in Parañaque City, Philippines: A Spatial Analysis. Trop. Med. Infect. Dis. 2023, 8, 66.

Abstract

Dengue infection is one of the most important vector-borne diseases worldwide and is a significant public health problem in the tropics. Mosquito control continues to be the primary approach to reducing the disease burden and the dengue virus (DENV) spread. Aside from the traditional larviciding and adulticiding interventions, autodissemination using pyriproxyfen-treated (AD-PPF) ovitraps is one of the promising methods to complement existing vector control strategies. Our paper assessed the efficacy of AD-PPF in reducing DENV infection in two barangays in Parañaque City. Using saliva samples from the participants from both the control and intervention sites, we collected the seroprevalence data for three months in each of the two years. Spatial analysis was conducted to determine hotspot areas and identify DENV infection distributions across the trial periods. Results showed that the intervention site was identified as having clustering of DENV infection in Month 0 of Year 1 and shifted to random dispersion of dengue cases at the end of Month 3 in Year 2. The disappearance of the clustering of the intervention site translates to a decrease in the cases of DENV infection relative to the control site. Furthermore, we also identified that DENV infection transmission occurs at a small-scale level that did not go beyond 86 meters. In conclusion, AD-PPF is suggested to be an effective strategy and may be used as an additional vector control approach, albeit in its short-term implementation.

Keywords

autodissemination; dengue; ovitraps; Philippines; pyriproxyfen; spatial analysis

Subject

Medicine and Pharmacology, Tropical Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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