Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Genomic Epidemiology of SARS-Cov-2 in Western Burkina Faso, West Africa

Yacouba Sawadogo
ORCID logo ,
Lokman Galal
ORCID logo ,
Essia Belarbi
,
Arsène Zongo
,
Grit Schubert
,
Fabian Leendertz
,
Abdoulie Kanteh
ORCID logo ,
Abdul Karim Sesay
,
Annette Erhart
,
Anne-Laure Bañuls
ORCID logo ,
Zekiba Tarnagda
ORCID logo ,
Sylvain Godreuil
ORCID logo ,
Halidou Tinto
,
Abdoul-Salam Ouedraogo
*
Version 1 : Received: 31 October 2022 / Approved: 2 November 2022 / Online: 2 November 2022 (11:14:27 CET)

A peer-reviewed article of this Preprint also exists.

Sawadogo, Y.; Galal, L.; Belarbi, E.; Zongo, A.; Schubert, G.; Leendertz, F.; Kanteh, A.; Sesay, A.K.; Erhart, A.; Bañuls, A.-L.; Tarnagda, Z.; Godreuil, S.; Tinto, H.; Ouedraogo, A.-S. Genomic Epidemiology of SARS-CoV-2 in Western Burkina Faso, West Africa. Viruses 2022, 14, 2788. Sawadogo, Y.; Galal, L.; Belarbi, E.; Zongo, A.; Schubert, G.; Leendertz, F.; Kanteh, A.; Sesay, A.K.; Erhart, A.; Bañuls, A.-L.; Tarnagda, Z.; Godreuil, S.; Tinto, H.; Ouedraogo, A.-S. Genomic Epidemiology of SARS-CoV-2 in Western Burkina Faso, West Africa. Viruses 2022, 14, 2788.

Abstract

Background: After its initial detection in Wuhan, China, in December 2019, SARS-CoV-2 has spread rapidly, causing successive epidemic waves worldwide. This study aims to provide a genomic epidemiology of SARS-CoV-2 in Burkina Faso. Methods: Three hundred and seventy-seven SARS-CoV-2 genomes obtained from PCR-positive nasopharyngeal samples (PCR cycle threshold score <35) collected between May 5, 2020, and January 31, 2022 were analysed. Genomic sequences were assigned to phylogenetic clades using NextClade and to Pango lineages using pangolin. Phylogenetic and phylogeographic analyses were performed to determine the geographical sources and time of virus introduction in Burkina Faso. Results: The analyzed SARS-CoV-2 genomes could be assigned to 10 phylogenetic clades and 27 Pango lineages already described worldwide. Our analyses revealed the important role of cross-border human mobility in the successive SARS-CoV-2 introductions in Burkina Faso from neighboring countries. Conclusion: This study provides additional insights into the genomic epidemiology of SARS-CoV-2 in West Africa. It highlights the importance of land travel in the spread of the virus and the need to rapidly implement preventive policies. Regional cross-border collaborations and the adherence of the general population to government policies are key to prevent new epidemic waves.

Keywords

COVID-19; SARS-CoV-2; Whole Genome Sequencing; Genomic epidemiology; West Africa, Burkina Faso

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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