Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance

Version 1 : Received: 4 October 2022 / Approved: 6 October 2022 / Online: 6 October 2022 (12:28:26 CEST)

A peer-reviewed article of this Preprint also exists.

Huang, J.; Ecker, G.F. A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance. Molecules 2023, 28, 495. Huang, J.; Ecker, G.F. A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance. Molecules 2023, 28, 495.

Abstract

The discovery of first ATP-binding cassette (ABC) transporter, whose overexpression in cancer cells is responsible for exporting anticancer drugs out of tumor cells, initiated enormous efforts to overcome tumor cell multidrug resistance (MDR) by inhibition of ABC-transporter. Because of its many physiological functions, diverse studies have been conducted on the mechanism, function and regulation of this important group of transmembrane transport proteins. In this review, we will focus on the structural aspects of this transporter superfamily. Since the resolution revolution of electron microscope, experimentally solved structures increased rapidly. A summary of the structures available and an overview of recent structure-based studies are provided. More specifically, the artificial intelligence (AI)-based predictions from AlphaFold 2 will be discussed.

Keywords

structure-based studies; ABC transporter; multidrug resistance (MDR); cancer therapy

Subject

Medicine and Pharmacology, Oncology and Oncogenics

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