Wang, C.; Fan, L.; Pan, Z.; Fan, S.; Shi, L.; Li, X.; Zhao, J.; Wu, L.; Yang, G.; Xu, C. Synthesis of Novel Indole Schiff Base Compounds and Their Antifungal Activities. Molecules2022, 27, 6858.
Wang, C.; Fan, L.; Pan, Z.; Fan, S.; Shi, L.; Li, X.; Zhao, J.; Wu, L.; Yang, G.; Xu, C. Synthesis of Novel Indole Schiff Base Compounds and Their Antifungal Activities. Molecules 2022, 27, 6858.
Wang, C.; Fan, L.; Pan, Z.; Fan, S.; Shi, L.; Li, X.; Zhao, J.; Wu, L.; Yang, G.; Xu, C. Synthesis of Novel Indole Schiff Base Compounds and Their Antifungal Activities. Molecules2022, 27, 6858.
Wang, C.; Fan, L.; Pan, Z.; Fan, S.; Shi, L.; Li, X.; Zhao, J.; Wu, L.; Yang, G.; Xu, C. Synthesis of Novel Indole Schiff Base Compounds and Their Antifungal Activities. Molecules 2022, 27, 6858.
Abstract
A series of novel indole Schiff base derivatives (2a–2t) containing a 1,3,4-thiadiazole scaffold modified with a thioether group were synthesized, and their structures were confirmed using FT-IR, 1H NMR, 13C NMR, andHR-MS. In addition, the antifungal activity of synthesized indole derivatives was investigated against Fusarium graminearum (F. graminearum), Fusarium oxysporum (F. oxysporum), Fusarium moniliforme (F. moniliforme),Curvularia lunata (C. lunata), and Phytophthora parasitica var. nicotiana (P. p. var. nicotianae) using the mycelium growth rate method. Among the synthesized indole derivatives, compound 2j showed the highest inhibition rates of 100%, 95.7%, 89%, and 76.5% at a concentration of 500 μg/mL against F. graminearum, F. oxysporum, F. moniliforme, and P. p. var. nicotianae, respectively. Similarly, compounds 2j and 2q exhibited higher inhibition rates of 81.9% and 83.7% at a concentration of 500 μg/mL against C. lunata. In addition, compound 2j has been recognized as a potential compound for further investigation in the field of fungicides.
Keywords
Antifungal activities; synthesis; indole Schiff base derivatives; 1,3,4-thiadiazole
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright:
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