Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives

Victor Manuylov
* ORCID logo ,
Vladimir Chulanov
ORCID logo ,
Ludmila Bezuglova
,
Elena Chub
,
Anastasia Karlsen
ORCID logo ,
Karen Kyuregyan
ORCID logo ,
Yulia Ostankova
ORCID logo ,
Alexander Semenov
,
Lyudmila Osipova
,
Tatjana Tallo
,
Irina Netesova
,
Artem Tkachuk
,
Vladimir Gushchin
ORCID logo ,
Sergey Netesov
,
Lars O. Magnius
,
Heléne Norder
ORCID logo
Version 1 : Received: 3 October 2022 / Approved: 5 October 2022 / Online: 5 October 2022 (10:44:12 CEST)

A peer-reviewed article of this Preprint also exists.

Manuylov, V.; Chulanov, V.; Bezuglova, L.; Chub, E.; Karlsen, A.; Kyuregyan, K.; Ostankova, Y.; Semenov, A.; Osipova, L.; Tallo, T.; Netesova, I.; Tkachuk, A.; Gushchin, V.; Netesov, S.; Magnius, L.O.; Norder, H. Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives. Viruses 2022, 14, 2465. Manuylov, V.; Chulanov, V.; Bezuglova, L.; Chub, E.; Karlsen, A.; Kyuregyan, K.; Ostankova, Y.; Semenov, A.; Osipova, L.; Tallo, T.; Netesova, I.; Tkachuk, A.; Gushchin, V.; Netesov, S.; Magnius, L.O.; Norder, H. Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives. Viruses 2022, 14, 2465.

Abstract

A total of 381 hepatitis B virus (HBV) DNA sequences collected from 9 groups of Siberian native populations were phylogenetically analyzed along with 179 HBV strains sampled in different urban populations of former western USSR republics and 50 strain from Central Asian republics and Mongolia. Different HBV subgenotypes predominated in various native Siberian populations. Subgenotype D1 was dominant in Altaian Kazakhs (100%), Tuvans (100%), and Teleuts (100%) of southern Siberia as well as in Dolgans and Nganasans (69%), who inhabit the polar Taimyr Peninsula. D2 was the most prevalent subgenotype in the combined group of Nenets, Komi, and Khants of the northern Yamalo-Nenets Autonomous Region (71%), and in Yakuts (36%) from northeastern Siberia. D3 was the main subgenotype in South Altaians (76%) and Buryats (40%) of southeastern Siberia, and in Chukchi (51%) of the Russian Far East. Subgenotype C2 was found in Taimyr (19%) and Chukchi (27%), while subgenotype A2 was common in Yakuts (33%). In contrast, D2 was dominant (56%) in urban populations of the former western USSR, and D1 (62%) in Central Asian republics and Mongolia. Statistical analysis demonstrated that the studied groups are epidemiologically isolated from each other and might have contracted HBV from different sources during the settlement of Siberia.

Keywords

hepatitis B virus; genotypes; subgenotypes; HBsAg subtypes; molecular epidemiology; Siberia; Siberian natives; aboriginal population

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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