Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Association between Diabetes Status and Breast Cancer in Us Adults: A Cross-Sectional Study

Version 1 : Received: 27 September 2022 / Approved: 30 September 2022 / Online: 30 September 2022 (08:40:03 CEST)

How to cite: Sun, X.; Hu, P.; Liu, X.; Liu, J.; Yan, Y.; Sun, C.; Yau, V.; Lowe, S.; Meng, M.; Liu, Z. Association between Diabetes Status and Breast Cancer in Us Adults: A Cross-Sectional Study. Preprints 2022, 2022090481. https://doi.org/10.20944/preprints202209.0481.v1 Sun, X.; Hu, P.; Liu, X.; Liu, J.; Yan, Y.; Sun, C.; Yau, V.; Lowe, S.; Meng, M.; Liu, Z. Association between Diabetes Status and Breast Cancer in Us Adults: A Cross-Sectional Study. Preprints 2022, 2022090481. https://doi.org/10.20944/preprints202209.0481.v1

Abstract

Abstract Objectives: The purpose of this study was to determine whether breast cancer and diabetes status are related in adult Americans. Methods: We conducted a cross-sectional study of 7,599 individuals from the National Health and Nutrition Examination Survey (NHANES). Diabetes was classified as type 2 diabetes and pre-diabetes. Both prediabetes and diabetes were diagnosed according to ADA 2014 guidelines. Multiple logistic regression analysis was used to explore the relationship between diabetes status and breast cancer. Results: We found that prediabetes (OR = 0. 60, 95% CI:(0. 40, 0. 88), P= 0. 009613) and non-diabetes (OR = 0.05.3,95% CI: (0.34, 0.83), P = 0. 006014) were associated with a reduced risk of breast cancer in comparison to Type 2 diabetes (literature). Prediabetes in non-Hispanic blacks was associated with a reduced risk of breast cancer (OR=0. 55,95%CI:0. 40-0. 75, P<0. 001). Using two segmented linear regression models to fit the relationship between BMI and breast cancer, we found that the relationship between BMI and breast cancer was nonlinear, but there was a threshold effect. The threshold effect analysis found that BMI affcted breast cancer at an inflection point 26. 3 Kg/m2. Adjusted OR (95% CI) on both sides of the turning point was 1. 0799 ( 1. 0029, 1. 1629 ) and 0. 9873 ( 0. 9638, 1. 0115 ), respectively. Conclusions: Diabetes status is associated with the risk of breast cancer development. Moreover, the risk of developing breast cancer steadily increased from nondiabetes to prediabetes and type 2 diabetes. In addition, the prevalence of breast cancer showed a gradual increase withincreasing BMI up to 26. 3 Kg/m2 with the highest prevalence of breast cancer. There was an inverse U-shaped relationship between BMI and the breast cancer prevalence.

Keywords

diabetes status; prediabetes; type 2 diabetes; breast cancer; NHANES

Subject

Biology and Life Sciences, Endocrinology and Metabolism

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