Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Impact of Sex in Left Atrial Indices for Prognosis of Heart Failure with Preserved Ejection Fraction

Version 1 : Received: 22 September 2022 / Approved: 23 September 2022 / Online: 23 September 2022 (08:09:57 CEST)

How to cite: Hoshida, S.; Tachibana, K.; Masunaga, N.; Shinoda, Y.; Minamisaka, T.; Inui, H.; Ueno, K.; Seo, M.; Yano, M.; Hayashi, T.; Nakagawa, A.; Nakagawa, Y.; Tamaki, S.; Yamada, T.; Yasumura, Y.; Sotomi, Y.; Hikoso, S.; Nakatani, D.; Sakata, Y. Impact of Sex in Left Atrial Indices for Prognosis of Heart Failure with Preserved Ejection Fraction. Preprints 2022, 2022090361 (doi: 10.20944/preprints202209.0361.v1). Hoshida, S.; Tachibana, K.; Masunaga, N.; Shinoda, Y.; Minamisaka, T.; Inui, H.; Ueno, K.; Seo, M.; Yano, M.; Hayashi, T.; Nakagawa, A.; Nakagawa, Y.; Tamaki, S.; Yamada, T.; Yasumura, Y.; Sotomi, Y.; Hikoso, S.; Nakatani, D.; Sakata, Y. Impact of Sex in Left Atrial Indices for Prognosis of Heart Failure with Preserved Ejection Fraction. Preprints 2022, 2022090361 (doi: 10.20944/preprints202209.0361.v1).

Abstract

Objective: We aimed to clarify the differences in the association between re-admission for heart failure (HF) and left atrial (LA) overload indices by sex in heart failure and a preserved ejection fraction (HFpEF). Methods: We analysed 898 HFpEF patients hospitalized for acute decompensated HF. Blood tests and transthoracic echocardiography were performed before discharge. The primary endpoint was re-admission for HF during the first year. Results: The ratio of diastolic elastance to arterial elastance (p=0.014), a relative index of LA pressure overload, in men and LA volume index (LAVI, p=0.020) in women were significant for re-admission for HF during the first year in the multivariable Fine-Gray analysis. Stroke volume (SV)/LA volume (LAV), another index for LAV overload, was not a significant prognostic factor of re-admission for HF during this time. Conclusion: LA overload was an important prognostic factor for HF re-readmission during the first year after enrolment in patients with HFpEF, but the indices relating to LA overload differed by sex.

Keywords

Ed/Ea; Fine-Gray model; HFpEF; LAVI; sex

Subject

MEDICINE & PHARMACOLOGY, Cardiology

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