Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Last but not Least Important Variant: The Most Negative Gibbs Energy of Binding Indicates the Greatest Infectivity of the BA.2.75 Compared with Other SARS-CoV-2 Variants

Version 1 : Received: 20 September 2022 / Approved: 21 September 2022 / Online: 21 September 2022 (09:44:34 CEST)

How to cite: Popovic, M. Last but not Least Important Variant: The Most Negative Gibbs Energy of Binding Indicates the Greatest Infectivity of the BA.2.75 Compared with Other SARS-CoV-2 Variants. Preprints 2022, 2022090318 (doi: 10.20944/preprints202209.0318.v1). Popovic, M. Last but not Least Important Variant: The Most Negative Gibbs Energy of Binding Indicates the Greatest Infectivity of the BA.2.75 Compared with Other SARS-CoV-2 Variants. Preprints 2022, 2022090318 (doi: 10.20944/preprints202209.0318.v1).

Abstract

Omicron BA.2.75 may become the next globally dominant strain of COVID-19 in 2022. BA.2.75 sub-variant has acquired more mutations (9) in spike protein and other genes of SARS-CoV-2 than any other variant. Thus, its chemical composition and thermodynamic properties have changed comparing to earlier variants. In this paper Gibbs energy of binding and antigen-receptor binding rate is reported for the BA.2.75 variant. Gibbs energy of binding (driving force of binding) of Omicron BA.2.75 variant is more negative than that of the competing variants BA.2 and BA.5.

Keywords

BA.2.75 variant; Gibbs energy of binding; binding rate; infectivity; SARS-CoV-2

Subject

LIFE SCIENCES, Virology

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