Version 1
: Received: 18 September 2022 / Approved: 19 September 2022 / Online: 19 September 2022 (05:28:34 CEST)
How to cite:
El Kazafy, S.; Fouad, Y.M.; Said, A.F.; Assal, H.H.; Ali, T.M.; Ahmed, A.E.; El Askary, A.; Ahmed, O.M. Clinical Laboratory Features of Moderate and Severe Patients with COVID-19 among a Cohort of Egyptian Population. Preprints2022, 2022090262. https://doi.org/10.20944/preprints202209.0262.v1
El Kazafy, S.; Fouad, Y.M.; Said, A.F.; Assal, H.H.; Ali, T.M.; Ahmed, A.E.; El Askary, A.; Ahmed, O.M. Clinical Laboratory Features of Moderate and Severe Patients with COVID-19 among a Cohort of Egyptian Population. Preprints 2022, 2022090262. https://doi.org/10.20944/preprints202209.0262.v1
El Kazafy, S.; Fouad, Y.M.; Said, A.F.; Assal, H.H.; Ali, T.M.; Ahmed, A.E.; El Askary, A.; Ahmed, O.M. Clinical Laboratory Features of Moderate and Severe Patients with COVID-19 among a Cohort of Egyptian Population. Preprints2022, 2022090262. https://doi.org/10.20944/preprints202209.0262.v1
APA Style
El Kazafy, S., Fouad, Y.M., Said, A.F., Assal, H.H., Ali, T.M., Ahmed, A.E., El Askary, A., & Ahmed, O.M. (2022). Clinical Laboratory Features of Moderate and Severe Patients with COVID-19 among a Cohort of Egyptian Population. Preprints. https://doi.org/10.20944/preprints202209.0262.v1
Chicago/Turabian Style
El Kazafy, S., Ahmad El Askary and Osama M. Ahmed. 2022 "Clinical Laboratory Features of Moderate and Severe Patients with COVID-19 among a Cohort of Egyptian Population" Preprints. https://doi.org/10.20944/preprints202209.0262.v1
Abstract
Abstract Aim: The study aimed to evaluate the clinical laboratory features of moderate and severe COVID-19 patients among a cohort of the Egyptian population. The study also aimed to assess the accuracy—sensitivity, specificity, and area under the curve (AUC) of various detected parameters in predicting the severity of COVID-19 infection. Patients and methods: One hundred diagnosed COVID-19 patients and fifty healthy participants in total were involved in current study. COVID-19 patients were categorized based on how severe their symptoms into two groups. Estimates were made for serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, lactate dehydrogenase (LDH) and C-reactive protein (CRP) as well as white blood cells (WBCs) count, lymphocytes count, and hemoglobin content (Hb) content. Results: COVID-19 patients displayed increased serum levels of liver enzymes and CRP as well as WBCs count when compared to healthy individuals. On the other hand, Hb content, lymphocytes count, and albumin level fell in all COVID-19 patients. The severe group showed a statistically significant rise in liver enzymes, WBCs, and CRP levels, compared with moderate group. WBCs and lymphocytes counts were closely correlated with age, ALT, LDH, and CRP in all cases. WBCs and lymphocytes counts also had a negative correlation with albumin Level. Additionally, WBCs count, lymphocytes count, LDH activity and CRP level have higher AUC in severe than in moderate cases. WBCs count, LDH activity and CRP level have AUC above 0.80 in the severe group. Conclusion: The current investigation found a significant correlation between WBCs count, lymphocytes count, CRP level and liver injury in COVID-19 patients. WBCs count, lymphocytes count, LDH activity and CRP level were effective indicators for determining the severity of COVID-19.
Keywords
Lymphocytes; liver function biomarkers; WBCs; and CRP
Subject
Medicine and Pharmacology, Clinical Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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