T-cell Response and Antibody Production by Booster COVID-19 Vaccination in Japanese Patients with Chronic Kidney Disease Treated with Hemodialysis

Ayumi Yoshifuji; Masataro Toda; Munekazu Ryuzaki; Emi Oyama; Kan Kikuchi; Toru Kawai; Ken Sakai; Masayoshi Koinuma; Kazuhiko Katayama; Yuki Uehara; Norio Ohmagari; Yoshihiko Kanno; Hirofumi Kon; Junko Tanaka; Toshio Shinoda; Yaoko Takano; Kazuhiko Hora; Yasushi Nakazawa; Naoki Hasegawa; Norio Hanafusa; Fumihiko Hinoshita; Keita Morikane; Shu Wakino; Hidetomo Nakamoto; Yoshiaki Takemoto

doi:10.20944/preprints202209.0101.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 4 September 2022 / Approved: 7 September 2022 / Online: 7 September 2022 (05:14:06 CEST)

Most studies on vaccines of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have focused on antibody, but cellular immunities are also critical. We aimed to evaluate the immune reactions of hemodialysis (HD) patients after the administration of the booster dose from the perspective of both humoral and cellular immunities. Hemodialysis patients (HD group) and age- and sex-matched non-dialysis individuals (control group) receiving three doses of BNT162b2 vaccine were measured for anti-SARS-CoV-2 immunoglobulin (IgG) and T-SPOTⓇ.COVID test (T-SPOT) before, 3 weeks, and 3 months after the booster dose. The HD group had significantly higher SARS-CoV-2 IgG levels 3 weeks and 3 months after the booster dose than the control group, although both groups had no difference in SARS-CoV-2 IgG levels before the booster dose. Moreover, the HD group had significantly higher T-SPOT levels before and 3 weeks after the booster dose than the control group, but the difference was not significantly different 3 months after the booster dose. Furthermore, the incidence rates of local and systemic adverse reactions were significantly higher in the HD group than in the control group. HD patients obtained higher SARS-CoV-2 IgG levels and SARS-COV-2-specific T-cell responses after the booster dose than control.

COVID-19; hemodialysis; vaccination; cellular immunity; humoral immunity; adverse reactions

Medicine and Pharmacology, Urology and Nephrology

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T-cell Response and Antibody Production by Booster COVID-19 Vaccination in Japanese Patients with Chronic Kidney Disease Treated with Hemodialysis

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