Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Trained Immunity as a Prospective Tool against Emerging Respiratory Pathogens

Version 1 : Received: 29 August 2022 / Approved: 30 August 2022 / Online: 30 August 2022 (03:55:12 CEST)

How to cite: Joseph, J. Trained Immunity as a Prospective Tool against Emerging Respiratory Pathogens. Preprints 2022, 2022080502 (doi: 10.20944/preprints202208.0502.v1). Joseph, J. Trained Immunity as a Prospective Tool against Emerging Respiratory Pathogens. Preprints 2022, 2022080502 (doi: 10.20944/preprints202208.0502.v1).

Abstract

The COVID-19 pandemic exposed the vulnerability of current vaccine technologies characterized by a slow onset of action and antigen-specific immune response. Although parental vaccines offer long-term protection against homologous strains, they rely exclusively on adaptive immune memory to produce neutralizing antibodies that are ineffective against new vaccine variants. Moreover, growing evidence highlights the multifaceted functions of trained immunity to elicit a rapid and enhanced innate response against unrelated stimuli or pathogens to subsequent triggers. This review discusses the protective role of trained immunity against respiratory pathogens and the experimental models essential for evaluating novel inducers of trained immunity. We further elaborate on the potential of trained immunity to leverage protection against emerging pathogens via recognition of diverse antigens by pathogen recognition receptors (PPRs) on innate immune cells. We also propose integrating trained- with adaptive- immunity to shape next-generation vaccines by coupling each one's unique characteristics.

Keywords

Trained immunity; innate immune memory; respiratory pathogens; BCG; next-generation vac-cines; COVID-19

Subject

LIFE SCIENCES, Immunology

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