Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Non-enzymatic Electrochemical Sensor of Cu@Co-MOF Composite for Glucose Detection with High Sensitivity and Selectivity

Version 1 : Received: 10 August 2022 / Approved: 16 August 2022 / Online: 16 August 2022 (03:26:09 CEST)

How to cite: Ma, Z.; Liu, B.; Jiao, H.; Xu, L. A Non-enzymatic Electrochemical Sensor of Cu@Co-MOF Composite for Glucose Detection with High Sensitivity and Selectivity. Preprints 2022, 2022080271 (doi: 10.20944/preprints202208.0271.v1). Ma, Z.; Liu, B.; Jiao, H.; Xu, L. A Non-enzymatic Electrochemical Sensor of Cu@Co-MOF Composite for Glucose Detection with High Sensitivity and Selectivity. Preprints 2022, 2022080271 (doi: 10.20944/preprints202208.0271.v1).

Abstract

The integration of metal nanoparticles and solid carriers can achieve ideal stability, high load and good conductivity. In this work, copper nanoparticles (Cu NPs) were sequentially deposited on a cobalt metal-organic framework (Co-MOF) by bonding with exposed imino groups, followed by a reduction reaction to prepare a new Cu@Co-MOF composite. Cu@Co-MOF acts as a non-enzymatic electrochemical sensor to detect glucose (Glu) in an alkaline medium. The composite working electrode of Cu@Co-MOF/GCE (GCE = glassy carbon electrode) improves the electrocatalytic activity for Glu oxidation. Cu@Co-MOF/GCE shows excellent electrocatalytic performances in Glu concentration ranging 0.005~1.8 mmol∙L−1 (mM): the sensitivities are 282.89 μA∙mM−1∙cm−2 in 0.005-0.4 mM Glu and 113.15 μA∙mM−1∙cm−2 in 0.4-1.8 mM Glu respectively with low detection limit of 1.6 μM (S/N = 3) and high selectivity and stability.

Keywords

non-enzymatic sensor; glucose; cobalt metal-organic framework; electrochemical detection

Subject

CHEMISTRY, Inorganic & Nuclear Chemistry

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