Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Fetal Macrosomia and Associated Factors to Perinatal Adverse Outcomes, in Yaounde, Cameroon : A Case Control Study

Version 1 : Received: 11 August 2022 / Approved: 15 August 2022 / Online: 15 August 2022 (11:56:31 CEST)

How to cite: Njom Nlend, A.E.; Gwodog, J.; Sandie, A.B. Fetal Macrosomia and Associated Factors to Perinatal Adverse Outcomes, in Yaounde, Cameroon : A Case Control Study. Preprints 2022, 2022080261. https://doi.org/10.20944/preprints202208.0261.v1 Njom Nlend, A.E.; Gwodog, J.; Sandie, A.B. Fetal Macrosomia and Associated Factors to Perinatal Adverse Outcomes, in Yaounde, Cameroon : A Case Control Study. Preprints 2022, 2022080261. https://doi.org/10.20944/preprints202208.0261.v1

Abstract

Objective To Identify risk factors of perinatal complications amongst macrosomic babies in a reference hospital structure. Method We conducted a case-control institutional based study. Cases and controls of singleton livebirths were extracted from the maternity registry from January 2017 to December 2019 The case population consisted of mother and child macrosomic couples with perinatal complications. The control group consisted of couples without perinatal complications. Matching was done on age and sex. The main primary end point was the risk factors for complications. Data were analyzed using R, software version3.0 in adjusted and unadjusted analysis with p<0.05 threshold considered statistically significant. Results Out of 362 couples, we had 186 cases and 176 controls. Maternal age ≥30 years (p=0.024); non-screening for gestational diabetes (p=0.027); history of caesarean section (p=0.041); weight gain ≥16 kg (p<0.001); maternal HIV (p=0.047); birth weight ≥4500g (p=0.015) and birth height ≥ 52.7 ±1.7cm (p=0.026) were risk factors. Conclusion The delivery of a macrosomic baby remains problematic in this setting. The improvement of the maternal-fetal prognosis requires quality prenatal surveillance and management by a multidisciplinary perinatal team involving obstetricians, endocrinologist, and neonatal pediatricians.

Keywords

fetal macrosomia; gestational diabetes; maternal obesity; birth weight; fetal growth

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

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