Version 1
: Received: 25 July 2022 / Approved: 26 July 2022 / Online: 26 July 2022 (10:46:17 CEST)
How to cite:
Ostrovskij, V.V.; Shulga, A.E.; Ulyanov, V.Y.; Zaretskov, V.V.; Bazhanov, S.P.; Likhachev, S.V. Morphological Features of Consolidation in Damaged Bodies of Thoracic and Lumbar Vertebras at Different Time Points After Injury. Preprints2022, 2022070405. https://doi.org/10.20944/preprints202207.0405.v1
Ostrovskij, V.V.; Shulga, A.E.; Ulyanov, V.Y.; Zaretskov, V.V.; Bazhanov, S.P.; Likhachev, S.V. Morphological Features of Consolidation in Damaged Bodies of Thoracic and Lumbar Vertebras at Different Time Points After Injury. Preprints 2022, 2022070405. https://doi.org/10.20944/preprints202207.0405.v1
Ostrovskij, V.V.; Shulga, A.E.; Ulyanov, V.Y.; Zaretskov, V.V.; Bazhanov, S.P.; Likhachev, S.V. Morphological Features of Consolidation in Damaged Bodies of Thoracic and Lumbar Vertebras at Different Time Points After Injury. Preprints2022, 2022070405. https://doi.org/10.20944/preprints202207.0405.v1
APA Style
Ostrovskij, V.V., Shulga, A.E., Ulyanov, V.Y., Zaretskov, V.V., Bazhanov, S.P., & Likhachev, S.V. (2022). Morphological Features of Consolidation in Damaged Bodies of Thoracic and Lumbar Vertebras at Different Time Points After Injury. Preprints. https://doi.org/10.20944/preprints202207.0405.v1
Chicago/Turabian Style
Ostrovskij, V.V., Sergey P. Bazhanov and Sergey V. Likhachev. 2022 "Morphological Features of Consolidation in Damaged Bodies of Thoracic and Lumbar Vertebras at Different Time Points After Injury" Preprints. https://doi.org/10.20944/preprints202207.0405.v1
Abstract
Reparative osteogenesis in the damaged vertebrae is a complex cascade of morphological and biochemical processes that result in the consolidation of the vertebral body. This research was aimed at studying the features of reparative osteogenesis in damaged thoracic and lumbar vertebral bodies at different time points after injury. We analyzed the morphological findings of the vertebral tissues harvested during surgical interventions in 43 patients with recent, subacute and long-standing injuries to thoracic and lumbar spine, and found that cell differentiation in osteogenesis is closely related to angiogenesis and the metabolic cascade. In areas with sufficient oxygenation, good partial pressure of oxygen, and active growth of microvasculature the normal cycle of development and differentiation of osteoblasts and osteocytes occurs, and hypoxia and acidosis lead to pathological osteogenesis. The reclination maneuver with dorsal tools on Day 10-12 of the injury may be ineffective due to the formation of adhesions between fragments, and reclination of the body of the damaged vertebra two weeks or more after the injury is apparently doomed to failure. Timely ventral fusion performed for objective indications is the key to successful rehabilitation of patients, on the one hand, and reduction of the surgical trauma volume in the future, on the other.
Medicine and Pharmacology, Orthopedics and Sports Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
