Aria, H.; Azizi, M.; Nazem, S.; Bahmanyar, M.; Moravej, A.; Pourjafarian, M.H.; Pezeshki, B.; Tavassoli, A.; Vakil, M.K.; Mansoori, Y. Cancer Stem Cells and Competing Endogenous RNAs. Preprints2022, 2022070353. https://doi.org/10.20944/preprints202207.0353.v1
APA Style
Aria, H., Azizi, M., Nazem, S., Bahmanyar, M., Moravej, A., Pourjafarian, M.H., Pezeshki, B., Tavassoli, A., Vakil, M.K., & Mansoori, Y. (2022). Cancer Stem Cells and Competing Endogenous RNAs. Preprints. https://doi.org/10.20944/preprints202207.0353.v1
Chicago/Turabian Style
Aria, H., Mohammad Kazem Vakil and Yaser Mansoori. 2022 "Cancer Stem Cells and Competing Endogenous RNAs" Preprints. https://doi.org/10.20944/preprints202207.0353.v1
Abstract
Cancer stem cells (CSCs) are one of the cell types that account for cancer heterogeneity. They arrest in the G0 phase and generate non-CSC progeny by self-renewing and pluripotency activity, resulting in tumor recurrence, metastasis, and chemoresistance. One CSC can stimulate tumor relapse and can re-grow a metastatic tumor. So, CSC is a promising target for eradicating tumors, and developing an anti-CSC method has become a top priority in cancer therapy. In recent years competing endogenous RNA (ceRNA) have emerged as an important class of post-transcriptional regulators that affect gene expression via competition for microRNA (miRNA) binding. Furthermore, aberrant ceRNA expression is associated with tumor progression. To overcome therapeutic resistance due to CSCs, we need to improve our existing understanding of the mechanisms by which ceRNAs are implicated in CSC-related relapse. Thus, this review was designed in order to discuss the role of ceRNAs in CSCs function. We reviewed the role of ceRNAs in acquiring CSCs characteristics in the form of different pathways including Rho GTPase/F-actin_ Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) (Hippo), Wnt/β-catenin pathway, transforming growth factor (TGF)-b–urothelial carcinoma-associated 1 (UCA1)–Slug pathway, etc. Finally, considering the comprehensive impacts of the ceRNA network on different pathways, a treatment strategy driving the ceRNA network might be effective. Targeting ceRNAs may open the path for new cancer therapeutic targets and can be used in clinical research.
Keywords
cancer stem cells; competing endogenous RNAs; ceRNA; lncRNA; micro-RNA; miRNA
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
