Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Hydrophilic Antimicrobial Coatings for Medical Leathers from Silica-Dendritic Polymer-Silver Nanoparticle Composite Xerogels

Michael Arkas
* ORCID logo ,
Georgia Kythreoti
,
Evangelos P. Favvas
ORCID logo ,
Konstantinos Giannakopoulos
,
Nafsica Mouti
,
Marina Arvanitopoulou
,
Ariadne Athanasiou
,
Marilina Douloudi
,
Eleni Nikoli
,
Michail Vardavoulias
,
Marios Dimitriou
,
Ioannis Karakasiliotis
ORCID logo ,
Victoria Ballén
ORCID logo ,
Sara M. Soto
ORCID logo
Version 1 : Received: 22 July 2022 / Approved: 25 July 2022 / Online: 25 July 2022 (04:38:06 CEST)

A peer-reviewed article of this Preprint also exists.

Arkas, M.; Kythreoti, G.; Favvas, E.P.; Giannakopoulos, K.; Mouti, N.; Arvanitopoulou, M.; Athanasiou, A.; Douloudi, M.; Nikoli, E.; Vardavoulias, M.; Dimitriou, M.; Karakasiliotis, I.; Ballén, V.; Soto González, S.M. Hydrophilic Antimicrobial Coatings for Medical Leathers from Silica-Dendritic Polymer-Silver Nanoparticle Composite Xerogels. Textiles 2022, 2, 464-485. Arkas, M.; Kythreoti, G.; Favvas, E.P.; Giannakopoulos, K.; Mouti, N.; Arvanitopoulou, M.; Athanasiou, A.; Douloudi, M.; Nikoli, E.; Vardavoulias, M.; Dimitriou, M.; Karakasiliotis, I.; Ballén, V.; Soto González, S.M. Hydrophilic Antimicrobial Coatings for Medical Leathers from Silica-Dendritic Polymer-Silver Nanoparticle Composite Xerogels. Textiles 2022, 2, 464-485.

Abstract

Hybrid organic-inorganic (dendritic polymer-silica) xerogels containing silver nanoparticles (Ag-Nps) were developed as antibacterial leather coatings. The preparation method is environmentally friendly, based on two biomimetic reactions. Silica gelation and spontaneous (Ag-Np) formation were both mediated by hyperbranched poly (ethylene imine) (PEI) scaffolds of variable Mw (2000-750000). The formation of precursor hydrogels was monitored by dynamic light scattering (DLS). The chemical composition of the xerogels was assessed by Infra-Red Spectroscopy (IR) and Energy-dispersive X-ray spectroscopy (EDS) while the uniformity of the coatings was established by scanning electron microscopy (SEM). Release properties of coated leather samples and overall behaviour in water in comparison to untreated analogs were investigated by UV-Vis spectroscopy. Antibacterial activity was tested towards Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, and antibiofilm properties against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Acinetobacter baumannii, Enterococcus faecalis while SARS-Cov-2 clinical isolate was employed for the first estimation of their antiviral potential. Toxicity was evaluated using the Jurkat E6.1-cell line. Finally, water contact angle measurements were implemented to determine the enhancement of the leather surface hydrophilicity caused by these composite layers. The final advanced products are intended for use in medical applications.

Keywords

dendrimers; hyperbranched; poly (ethylene imine); xerogels; antibacterial; SARS COVID-19 virus; antibiofilm; antiviral; water permeability; surface hydrophilicity

Subject

Chemistry and Materials Science, Applied Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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