Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Biocompatibility of Ceramic Materials in CaO-P2O5 System, Obtained via Heat Treatment of Cement-Salt Stone

Otabek Toshev
* ORCID logo ,
Tatiana Safronova
ORCID logo ,
Maksim Kaimonov
ORCID logo ,
Tatiana Shatalova
ORCID logo ,
Elena Klimashina
,
Yulia Lukina
ORCID logo ,
Konstantin Malyutin
ORCID logo
Version 1 : Received: 1 July 2022 / Approved: 5 July 2022 / Online: 5 July 2022 (13:13:30 CEST)

A peer-reviewed article of this Preprint also exists.

Toshev, O.; Safronova, T.; Kaimonov, M.; Shatalova, T.; Klimashina, E.; Lukina, Y.; Malyutin, K.; Sivkov, S. Biocompatibility of Ceramic Materials in Ca2P2O7–Ca(PO3)2 System Obtained via Heat Treatment of Cement-Salt Stone. Ceramics 2022, 5, 516-532. Toshev, O.; Safronova, T.; Kaimonov, M.; Shatalova, T.; Klimashina, E.; Lukina, Y.; Malyutin, K.; Sivkov, S. Biocompatibility of Ceramic Materials in Ca2P2O7–Ca(PO3)2 System Obtained via Heat Treatment of Cement-Salt Stone. Ceramics 2022, 5, 516-532.

Abstract

Biocompatibility of ceramic materials in CaO-P2O5 system was investigated using different methods, including in vitro and in vivo tests. Ceramics based on calcium pyrophosphate Ca2P2O7 were obtained by annealing cement-salt stone from highly concentrated hardening suspensions (HCHS). Cement-salt stone was prepared using powder mixtures of calcium citrate tetrahydrate Ca3(C6H5O7)2·4H2O and monocalcium phosphate monohydrate (MCPM) Ca(H2PO4)2·H2O. These salts were mixed with each other in such a way that calcium pyrophosphate and calcium polyphosphate were present in the final ceramic product in the following weight ratios: Ca(PO3)2/Ca2P2O7 = 0/100; 5/95; 10/90 and 20/80. Distilled water was added to a homogenized powder mixtures of Ca3(C6H5O7)2·4H2O and Ca(H2PO4)2·H2O by a water/solid ratio of 0,5 by weight. The obtained suspensions were shaped using silicon molds and left to dry in air for a week. The phase composition of the obtained samples of cement-salt stone was represented by brushite CaHPO4·2H2O, monetite CaHPO4, calcium citrate tetrahydrate Ca3(C6H5O7)2·4H2O and monocalcium phosphate monohydrate Ca(H2PO4)2·H2O. According to the XRD data, the phase composition of ceramic materials after annealing in the temperature range of 800-1000 0C was mainly represented by the β-Ca2P2O7 phase. In vivo tests shown that obtained ceramic materials can be recommended for regenerative treatments for bone defects.

Keywords

calcium pyrophosphate; calcium polyphosphate; biocompatibility; bone implants; regenerative medicine

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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