N-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry

Federico Cuccu; Francesco Basoccu; Claudia Fattuoni; Andrea Porcheddu

doi:10.20944/preprints202207.0014.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 30 June 2022 / Approved: 1 July 2022 / Online: 1 July 2022 (12:47:45 CEST)

The acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to depict a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely N-formylsaccharin, N-acetylsaccharin and N-propionylsaccharin. This protocol furnishes a valuable solventless alternative to the existing processes and aims to be highly beneficial in multi-step procedures due to its rapid and user-friendly workup.

formamides; formylation; acylation; mechanochemistry; saccharin

CHEMISTRY, Organic Chemistry

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N-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry

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