Version 1
: Received: 30 June 2022 / Approved: 1 July 2022 / Online: 1 July 2022 (12:47:45 CEST)
How to cite:
Cuccu, F.; Basoccu, F.; Fattuoni, C.; Porcheddu, A. N-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry. Preprints2022, 2022070014. https://doi.org/10.20944/preprints202207.0014.v1.
Cuccu, F.; Basoccu, F.; Fattuoni, C.; Porcheddu, A. N-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry. Preprints 2022, 2022070014. https://doi.org/10.20944/preprints202207.0014.v1.
Cite as:
Cuccu, F.; Basoccu, F.; Fattuoni, C.; Porcheddu, A. N-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry. Preprints2022, 2022070014. https://doi.org/10.20944/preprints202207.0014.v1.
Cuccu, F.; Basoccu, F.; Fattuoni, C.; Porcheddu, A. N-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry. Preprints 2022, 2022070014. https://doi.org/10.20944/preprints202207.0014.v1.
Abstract
The acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to depict a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely N-formylsaccharin, N-acetylsaccharin and N-propionylsaccharin. This protocol furnishes a valuable solventless alternative to the existing processes and aims to be highly beneficial in multi-step procedures due to its rapid and user-friendly workup.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.