Submitted:
30 June 2022
Posted:
01 July 2022
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Abstract
The acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to depict a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely N-formylsaccharin, N-acetylsaccharin and N-propionylsaccharin. This protocol furnishes a valuable solventless alternative to the existing processes and aims to be highly beneficial in multi-step procedures due to its rapid and user-friendly workup.
Keywords:
formamides
; formylation
; acylation
; mechanochemistry
; saccharin
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