Submitted:
30 June 2022
Posted:
01 July 2022
You are already at the latest version
Abstract
The acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to depict a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely N-formylsaccharin, N-acetylsaccharin and N-propionylsaccharin. This protocol furnishes a valuable solventless alternative to the existing processes and aims to be highly beneficial in multi-step procedures due to its rapid and user-friendly workup.
Keywords:
formamides
; formylation
; acylation
; mechanochemistry
; saccharin
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
