Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Fluid Gas Exchange for Flap Closure of Idiopathic Macular Hole

Version 1 : Received: 10 June 2022 / Approved: 13 June 2022 / Online: 13 June 2022 (05:35:46 CEST)

How to cite: Wu, T.; Peng, K. Fluid Gas Exchange for Flap Closure of Idiopathic Macular Hole. Preprints 2022, 2022060170 (doi: 10.20944/preprints202206.0170.v1). Wu, T.; Peng, K. Fluid Gas Exchange for Flap Closure of Idiopathic Macular Hole. Preprints 2022, 2022060170 (doi: 10.20944/preprints202206.0170.v1).

Abstract

Purpose: We evaluated the outcomes of fluid-gas exchange (FGE) for long-term flap closure of idiopathic macular hole (MH) after the inverted internal limiting (ILM) flap technique. Methods: We included eyes showed flap closure without complete MH closure, connection of the apart macular tissue, 1 month postoperatively after the inverted ILM flap technique. The eyes stayed at flap closure at 2 months postoperatively further underwent in-office FGE with 16% C3F8. Results: Among 10 eyes, 5 eyes (50%) showed flap closure at 2 months postoperatively further underwent FGE for complete MH closure while the remaining 5 eyes (50%) progressed directly at 2 months postoperatively. The improvement in vision of all flap closure from baseline was significant (p=0.015), with the mean baseline vision was 1.19 [Snellen equivalent (SE), 20/307] ± 0.52 logMAR and the mean final vision being 0.63 (SE, 20/85) ± 0.38 logMAR. The group that underwent FGE showed a better final vision of 0.45 (SE, 20/75) ± 0.23 logMAR than the group that didn’t undergo FGE (0.81 [SE, 20/128] ±0.44 logMAR). All eyes achieved complete MH closure, including the eyes that underwent FGE in a mean period of 5.60 months (range 3-10 months) after the inverted ILM flap technique. The eyes that underwent FGE achieved higher rate of foveal restoration [complete external limiting membrane (ELM): 80%; complete ellipsoid zone (EZ): 60%] than those that didn’t receive FGE (complete ELM: 40%; complete EZ: 10%). Conclusions: Eyes that underwent FGE accelerated complete MH closure and showed better final vision and fovea l restoration.

Keywords

Fluid gas exchange; flap closure; idiopathic macular hole; vitrectomy; inverted internal limiting membrane flap technique

Subject

MEDICINE & PHARMACOLOGY, Ophthalmology

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