Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Impact of COVID-19 Infection on Cognitive Function and the Implication for Rehabilitation: a Systematic Review and Meta-Analysis

Version 1 : Received: 31 May 2022 / Approved: 1 June 2022 / Online: 1 June 2022 (05:50:58 CEST)

A peer-reviewed article of this Preprint also exists.

Houben, S.; Bonnechère, B. The Impact of COVID-19 Infection on Cognitive Function and the Implication for Rehabilitation: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health 2022, 19, 7748. Houben, S.; Bonnechère, B. The Impact of COVID-19 Infection on Cognitive Function and the Implication for Rehabilitation: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health 2022, 19, 7748.

Journal reference: Int. J. Environ. Res. Public Health 2022, 19, 7748
DOI: 10.3390/ijerph19137748

Abstract

There is mounting evidence that patients with severe COVID-19 disease may have symptoms that continue beyond the acute phase, extending into the early chronic phase. Often referred to as 'Long COVID'. Simultaneously, case investigations have shown that COVID-19 individuals might have a variety of neurological problems. The accurate and accessible assessment of cognitive function in patients post COVID-19 infection is thus of increasingly high importance for both public and individual health. Little is known about the influence of COVID-19 on the general cognitive levels but more importantly, at sub functions level. Therefore, we first aim to summarize current level of evidence supporting a negative impact of COVID-19 infection on cognitive functions. 27 studies have been included in the systematic review representing a total of 94,103 participants (90,317 COVID-19 patients and 3,786 healthy controls). We then performed a meta-analysis summarizing the results of 5 studies (959 participants, 513 patients) to quantify the impact of COVID-19 on cognitive functions. The overall effect, expressed in Standardized Mean Differences, is -0.56 [95%CI -0.79 ; -0.34]. To prevent disability, we finally discuss the different approaches available in rehabilitation to help these patients and to avoid long-term complication.

Keywords

Long-COVID; cognitive disorders; rehabilitation

Subject

MEDICINE & PHARMACOLOGY, Psychiatry & Mental Health studies

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