Version 1
: Received: 25 May 2022 / Approved: 27 May 2022 / Online: 27 May 2022 (11:59:25 CEST)
Version 2
: Received: 23 April 2023 / Approved: 24 April 2023 / Online: 24 April 2023 (03:23:17 CEST)
Simion, L.; Ionescu, S.; Chitoran, E.; Rotaru, V.; Cirimbei, C.; Madge, O.-L.; Nicolescu, A.C.; Tanase, B.; Dicu-Andreescu, I.-G.; Dinu, D.M.; et al. Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage. Medicina 2023, 59, 1530, doi:10.3390/medicina59091530.
Simion, L.; Ionescu, S.; Chitoran, E.; Rotaru, V.; Cirimbei, C.; Madge, O.-L.; Nicolescu, A.C.; Tanase, B.; Dicu-Andreescu, I.-G.; Dinu, D.M.; et al. Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage. Medicina 2023, 59, 1530, doi:10.3390/medicina59091530.
Simion, L.; Ionescu, S.; Chitoran, E.; Rotaru, V.; Cirimbei, C.; Madge, O.-L.; Nicolescu, A.C.; Tanase, B.; Dicu-Andreescu, I.-G.; Dinu, D.M.; et al. Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage. Medicina 2023, 59, 1530, doi:10.3390/medicina59091530.
Simion, L.; Ionescu, S.; Chitoran, E.; Rotaru, V.; Cirimbei, C.; Madge, O.-L.; Nicolescu, A.C.; Tanase, B.; Dicu-Andreescu, I.-G.; Dinu, D.M.; et al. Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage. Medicina 2023, 59, 1530, doi:10.3390/medicina59091530.
Abstract
Background: This literature review investigates qualitative and quantitative uses of indocyanine green (ICG) in surgical treatment, as this novel technique has become increasingly popular in ORs (operating rooms) worldwide due to its many advantages. Method: An extensive literature review was performed by searching for relevant terms in 5 international databases (www.pubmed.gov, www.sciencedirect.com, www.scopus.com, www.Oxfordjournals.com, www.reaxys.com). The results of this search were summarized into the main advantages of employing ICG in colorectal surgery as follows: a) intraoperative fluorescence angiography capability; b) fluorescence-guided identification of lymph node involvement in colorectal cancer and the sentinel lymph node method; c) positive fluorescence flagging of a liver tumour as small as "only" 200 tumour cells; d) facilitation of fistula diagnosis; and e) tumour tattooing. Moreover, in addition to qualitative intraoperative ICG use, this technique can be combined with quantitative methods and parameters, such as maximum intensity, relative maximum intensity, and different inflow parameters (time-to-peak, slope, and t1/2max). The conclusion of this article is that fluorescence surgery with ICG aided by near-infrared (NIR) light is a relatively recent technology, an advantage of which is improving the specific anatomic and functional information provided, thus allowing more comprehensive and safer tumour removal as well as preservation of important structures.
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Sinziana Ionescu
Commenter's Conflict of Interests: Author