Chernov, V.; Dudnikova, E.; Zelchan, R.; Medvedeva, A.; Rybina, A.; Bragina, O.; Goldberg, V.; Muravleva, A.; Sörensen, J.; Tolmachev, V. Phase I Clinical Trial Using [99mTc]Tc-1-thio-D-glucose for Diagnosis of Lymphoma Patients. Pharmaceutics2022, 14, 1274.
Chernov, V.; Dudnikova, E.; Zelchan, R.; Medvedeva, A.; Rybina, A.; Bragina, O.; Goldberg, V.; Muravleva, A.; Sörensen, J.; Tolmachev, V. Phase I Clinical Trial Using [99mTc]Tc-1-thio-D-glucose for Diagnosis of Lymphoma Patients. Pharmaceutics 2022, 14, 1274.
Chernov, V.; Dudnikova, E.; Zelchan, R.; Medvedeva, A.; Rybina, A.; Bragina, O.; Goldberg, V.; Muravleva, A.; Sörensen, J.; Tolmachev, V. Phase I Clinical Trial Using [99mTc]Tc-1-thio-D-glucose for Diagnosis of Lymphoma Patients. Pharmaceutics2022, 14, 1274.
Chernov, V.; Dudnikova, E.; Zelchan, R.; Medvedeva, A.; Rybina, A.; Bragina, O.; Goldberg, V.; Muravleva, A.; Sörensen, J.; Tolmachev, V. Phase I Clinical Trial Using [99mTc]Tc-1-thio-D-glucose for Diagnosis of Lymphoma Patients. Pharmaceutics 2022, 14, 1274.
Abstract
Like 18F-FDG, 99mTc-1-thio-D-glucose (99mTc-TG) also binds to GLUT receptors. The aim of this Phase I study was to evaluate the safety, biodistribution and dosimetry of 99mTc-TG. Twelve lym-phoma patients were injected with 729±102 MBq 99mTc-TG. Whole-body planar imaging was per-formed in 10 patients at 2, 4, 6 and 24 h after injection. In all 12 patients SPECT/CT (at 2 h) and SPECT (at 4 and 6 h) imaging was performed. Vital signs and possible side effects were monitored during imaging and up to 7 days after injection. 99mTc-TG injections were well tolerated and no side effects or alterations in blood and urine analyses data were observed. The highest absorbed dose was in the kidneys and urinary bladder wall, followed by the adrenals, prostate, bone mar-row, lungs, myocardium, ovaries, uterus, liver and gall bladder wall. 99mTc-TG SPECT/CT re-vealed foci of high activity uptake in the lymph nodes of all nine patients with known nodal le-sions. Extranodal lesions were detected in all nine cases. In one patient, a lesion in the humerus head, which was not detected by CT, was visualized using 99mTc-TG. Potentially, 99mTc-TG SPECT can be considered as an additional diagnostic method for imaging GLUT receptors in lymphoma patients.
Medicine and Pharmacology, Pharmacology and Toxicology
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