Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

COVID-19 and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure

Version 1 : Received: 1 May 2022 / Approved: 4 May 2022 / Online: 4 May 2022 (14:17:42 CEST)
Version 2 : Received: 21 May 2022 / Approved: 23 May 2022 / Online: 23 May 2022 (11:00:06 CEST)

How to cite: Roy, B.; Runa, S.A. COVID-19 and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure. Preprints 2022, 2022050014 (doi: 10.20944/preprints202205.0014.v1). Roy, B.; Runa, S.A. COVID-19 and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure. Preprints 2022, 2022050014 (doi: 10.20944/preprints202205.0014.v1).

Abstract

Since the discovery of the Coronavirus disease 2019 (COVID-19) outbreak, a vast majority of studies have been carried out that confirmed the worst outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in people with preexisting health conditions, including diabetes. Both diabetes and SARS-CoV-2 have their independent ability to induce the pathogenesis of multi-system organ dysfunction, while the co-existence of these two culprits can accelerate the pathophysiology and magnify the severity of the diseases. However, the exact pathophysiology of multi-system organ failure in diabetic patients after SARS-CoV-2 infection is still obscure. This review summarized the organ-specific possible molecular mechanisms of SARS-CoV-2 and diabetes-induced pathophysiology of several diseases, including the lungs, heart, kidney, brain, eyes, gastrointestinal system, and bones and subsequent manifestation of multi-system organ failure.

Keywords

COVID-19; SARS-CoV-2; Diabetes; Neurological dysfunction; Cardiovascular complications; Pulmonary dysfunction; Renal dysfunction; bone loss; Eye disease; Gastrointestinal complications

Subject

LIFE SCIENCES, Molecular Biology

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