Version 1
: Received: 12 April 2022 / Approved: 18 April 2022 / Online: 18 April 2022 (03:38:08 CEST)
How to cite:
Quazi, S.; Gavas, S.; Farasati Far, B.; Malik, J.; Rashid, M. The Discovery of Novel Antimicrobial Agents by The Application of Isocyanide Based Multicomponent Reactions. Preprints2022, 2022040151. https://doi.org/10.20944/preprints202204.0151.v1.
Quazi, S.; Gavas, S.; Farasati Far, B.; Malik, J.; Rashid, M. The Discovery of Novel Antimicrobial Agents by The Application of Isocyanide Based Multicomponent Reactions . Preprints 2022, 2022040151. https://doi.org/10.20944/preprints202204.0151.v1.
Cite as:
Quazi, S.; Gavas, S.; Farasati Far, B.; Malik, J.; Rashid, M. The Discovery of Novel Antimicrobial Agents by The Application of Isocyanide Based Multicomponent Reactions. Preprints2022, 2022040151. https://doi.org/10.20944/preprints202204.0151.v1.
Quazi, S.; Gavas, S.; Farasati Far, B.; Malik, J.; Rashid, M. The Discovery of Novel Antimicrobial Agents by The Application of Isocyanide Based Multicomponent Reactions . Preprints 2022, 2022040151. https://doi.org/10.20944/preprints202204.0151.v1.
Abstract
Multicomponent reactions (MCR) have been used to synthesis a wide range of analogs from several classes of heterocyclic compounds, with multifaceted medicinal uses. The synthesis of highly functionalized molecules in a single pot is a unique property of MCR, allowing researchers to quickly assemble libraries of compounds of biological interest and uncover novel leads as possible therapeutic agents. Isocyanide-based multicomponent reactions have proven to be extremely effective at swiftly specifying members of compound libraries, particularly in discovery of drug . The understanding of structure-activity correlations that drive the development of new goods and technology, requires structural variety in these libraries. In current world, antibiotic resistance is a major ongoing problem which is developing a problematic scenario in public health. The implementation of isocyanide based multicomponent reactions uphold a significant potential in this regard. By utilizing such reactions, new antimicrobial compounds can be discovered and fight against such concerns. This study discusses recent developments in antimicrobial medication discovery using isocyanide-based multicomponent reactions (IMCRs). Furthermore, the article emphasizes the potential of IMCRs in the near future.
Keywords
Isocyanide-based multicomponent reactions; Antimicrobial Discovery; Antibiotic Resistance; Public Health
Subject
CHEMISTRY, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
